2020年5月27日讯 /生物谷BIOON /——当一个人被新型冠状病毒SARS-CoV-2感染时,病原体在感染者的细胞内迅速增殖。要做到这一点,病毒必须繁殖它的遗传物质,它是由一条长长的RNA链组成的。这个过程是由病毒"复印机"--即所谓的聚合酶来完成的。德国哥廷根马克斯普朗克生物物理化学研究所的Patrick Cramer领导的研究人...
参考资料: 【1】How the coronavirus multiplies its genetic material 【2】Hillen, H.S., Kokic, G., Farnung, L. et al. Structure of replicating SARS-CoV-2 polymerase. Nature (2020). https://doi.org/10.1038/s41586-020-2368-8 【3】Virus multiplication in 3-D 【4】COVID-19 puts new ...
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates. Afte...
First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation centre through wastewater surveillance in Bangladeshdoi:10.1101/2020.09.14.20194696Firoz AhmedMd IslamManish KumarMd JakariyaCold Spring Harbor Laboratory Press
The very first sample that tested positive for the genetic material of SARS-CoV-2 was a urine sample collected as early as Sept 12, 2019, from an 8-month-old child whose serum also tested positive for IgG and IgM antibodies against the virus. ...
Wastewater surveillance for SARS-CoV-2 provides early warnings of emerging variants of concerns and can be used to screen for novel cryptic linked-read mutations, which are co-occurring single nucleotide mutations that are rare, or entirely missing, in existing SARS-CoV-2 databases. While previous...
然而,COVID-19危机对许多人,尤其是癌症患者的健康和福祉造成了负面影响,越来越多的证据表明,一些患有活动性癌症或曾患癌症的人在接种COVID-19疫苗后病情加重。近期发表的一项研究旨在强调研究和比较COVID-19疫苗接种后癌症并发症的发生率与SARS-CoV-2感染后类似事件的发生率(未接种人群)的迫切需要。
Genomic surveillance has shaped our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS-CoV-2 genomic surveillance and genomic data using a collection of country-specifi
The genetic material of the SARS-CoV-2 is positive single-stranded RNA (ssRNA) and its virion has four main structural proteins including nucleocapsid (N) protein, transmembrane (M) protein, envelope (E) protein, and the spike (S) protein (Fig. 2). Download: Download high-res image (217...
3. Genetic diversity of SARS-CoV-2 Similar to the other RNA viruses, genetic diversity in SARS-CoV-2 is critical for its fitness, survival, and probably its pathogenesis. In a study performed on the origin of SARS-CoV-2, it was shown that random mutations and recombination are two main ...