Emerging viral infections have been known as a significant threat of recent years. Coronavirus-2 (SARS-CoV-2) was initially recognized in China and infected a large population through inhalation of droplets. Massive global deaths, multiple mutations, and the mysterious nature of the virus require ...
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital protein
研究人员认为蝙蝠冠状病毒可能是SARS-CoV-2的演化前体,此前研究发现蝙蝠病毒RaTG13与SARS-CoV-2的亲缘关系是已知关系中最近的。不过,尚不清楚SARS-CoV-2如何演化到可以感染人类,也不清楚它是通过某个中间宿主还是直接传播给了人类。 2020年7月9日,来自英国伦敦弗朗西斯·克里克研究所Antoni Wrobel和Donald Benton团队...
Structurally, SARS-CoV-2 has round or elliptic and often pleomorphic form, with a diameter of approximately 60–140 nm and is sensitive to ultraviolet rays and heat (Yu et al., 2014). The complete structure consists of mainly four components: spike (S), nucleocapsid (N), membrane (M), ...
严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 感染是 2019 年冠状病毒病 (COVID-19) 的起源,炎症反应加剧、持续的病毒载量和抗病毒防御途径缺陷等疾病恶化因素可能导致急性呼吸衰竭、败血症和死亡。因此,确定潜在的细胞和分子机制对于了解COVID-19病理生理学和指导适当疗法的开发至关重要。本研究收集了 15 名...
We discovered that SARS-CoV-2 infection causes DNA damage both in cultured cells and in vivo. Mechanistically, SARS-CoV-2 degrades the enzyme CHK1, which leads to a reduction in dNTPs and impaired DNA replication. Moreover, inhibition of the formation of
SARS-CoV-2 S Protein and ACE2 Binding Assay The SARS-CoV-2 Spike protein and ACE2 binding assay is used to measure the direct binding of potential therapeutics to the Spike protein receptor-binding domain or ACE2 to determine the kinetics of the interaction or to measure whether the test ...
The SARS-CoV is a novel coronavirus with a large (∼30 thousand nucleotides) positive-sense, single-stranded RNA containing 14 functional open reading frames (ORFs) of which 2 large ORFs constitute the replicase gene which encodes proteins required for viral RNA syntheses. T 展开 关键词:...
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High-resolution structural information is critical for rapid development of vaccines and therapeutics against emerging human pathogens. Structural biology methods have been at the forefront of research on SARS-CoV-2 since the beginning of the C...