SAIGE-GENE+算法具有如下特性:1) 基于混合模型,可以描述样本之间的遗传关联性;2) 支持Burden tests, SKAT与SKAT-O检验方法,因而在不同的遗传模型中都具有较好的统计效力;3) 允许用户基于不同的先验知识,比如遗传位点的功能信息,来设定多种...
An existing method, SAIGE-GENE, performs well when testing variants with minor allele frequency (MAF)≤1%, but inflation is observed in variance component set-based tests when restricting to variants with MAF≤0.1% or 0.01%. Here, we propose SAIGE-GENE+ with greatly improved typeI error ...
SAIGE-GENE (now known as SAIGE-GENE+) are new method extension in the R package for testing rare variant in set-based tests. performs BURDEN, SKAT, and SKAT-O tests allows for tests on multiple minor allele frequencies cutoffs and functional annotations ...
1.以软件为主体,介绍了统计遗传中gene-based方法思想。2.介绍了软件的特性及算法,及应用场景。3.涉及了一些统计学知识和计算机相关的介绍。, 视频播放量 1111、弹幕量 0、点赞数 37、投硬币枚数 23、收藏人数 57、转发人数 12, 视频作者 进化之眼bsz, 作者简介 Doctor 进