Compared with FeS2 and Fe3S4, the mixed Fe-valence states of Fe7S8 is expected to provide multiple active sites, large specific surface area, and the greatest redox reversibility, which should be qualified for being regarded as the nanozyme for potentially exhibiting the admirable enzyme-like ...
Immunomodulatory drugs, proteasome inhibitors, histone deacetylate inhibitors, and monoclonal antibodies are currently used to treat patients with symptomatic MM7. Despite advances in current MM treatment options, the disease eventually relapses and drug resistance develops, leading to patient death due...
Tetralogy of Fallot (TOF) is one of the most prevalent congenital heart defects, with adverse cardiac remodeling and long-term cardiac complications. Here, searching for pathomechanisms, we find upregulated bublin coiled-coil protein (BBLN) in heart specimens of TOF patients with cyanosis, which ...
The frequency of fungal infections is increasing due to immunodeficiency viruses and immunosuppressive drugs. The most common fungal infection of the oral cavity is candidiasis. The existence ofCandidacan be a part of normal commensal; hence, the isolation ofCandidain the absence of clinical symptoms ...
16,17,18,19 Given that most cutaneous toxicities induced by drugs (e.g., everolimus, adriamycin liposome, and capecitabine) are caused by cellular processes targeting keratinocytes,20,21,22 we initially sought to test the direct effect of sorafenib on keratinocytes by employing human primary ...
不再以叙述人的语气，而是将感情整个融入说话或文章中，直接和所涉及的人或者物说话，也就是对本来不在面前的人或物直接呼唤，并且跟他说话。需要注意的是，呼告这种修辞手法，必须是在情绪激动，而且不吐不快时才适合运用，否则会被认为无病呻吟，反而得到负面效果。根据上述定义，下列使用了呼告的是：
Materials and methods Selection of the panel members In May 2018, the SARNePI appointed two co-chairs (coordinators of the SARNePI Pediatric Neurological Protection and Drugs study group) to carry out this project. The selection of panel members was conducted by the co-chairs, considering expertis...
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies ...
An examination for potential direct or indirect adverse effects on the immune system (immunotoxicity) is an established component of nonclinical testing to support safe use of new drugs. Testing recommendations occur in various regulatory guidance documents, especially ICH S8, and these will be ...
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by organoid models of