Compared with FeS2 and Fe3S4, the mixed Fe-valence states of Fe7S8 is expected to provide multiple active sites, large specific surface area, and the greatest redox reversibility, which should be qualified for being regarded as the nanozyme for potentially exhibiting the admirable enzyme-like ...
Tetralogy of Fallot (TOF) is one of the most prevalent congenital heart defects, with adverse cardiac remodeling and long-term cardiac complications. Here, searching for pathomechanisms, we find upregulated bublin coiled-coil protein (BBLN) in heart specimens of TOF patients with cyanosis, which ...
16,17,18,19 Given that most cutaneous toxicities induced by drugs (e.g., everolimus, adriamycin liposome, and capecitabine) are caused by cellular processes targeting keratinocytes,20,21,22 we initially sought to test the direct effect of sorafenib on keratinocytes by employing human primary ...
Materials and methods Selection of the panel members In May 2018, the SARNePI appointed two co-chairs (coordinators of the SARNePI Pediatric Neurological Protection and Drugs study group) to carry out this project. The selection of panel members was conducted by the co-chairs, considering expertis...
for their capacity to convert a broad variety of carcinogens, which can lead to their activation or inactivation12. Recent studies have demonstrated that human gut bacteria also have a large potential to metabolize chemically diverse compounds, such as medical drugs, and that the resulting products ...
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies ...
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by organoid models of
An examination for potential direct or indirect adverse effects on the immune system (immunotoxicity) is an established component of nonclinical testing to support safe use of new drugs. Testing recommendations occur in various regulatory guidance documents, especially ICH S8, and these will be ...
but also confer oncogenic properties to p53 mutants. Since p53 is mutated and inactivated in most malignant tumors, it has been a very attractive target for developing new anti-cancer drugs. However, until recently, p53 was considered an “undruggable” target and little progress has been made ...
further expansion of hospitalized critically-ill individuals6. HAIs due to AROs in the ICU can be difficult to treat due to limited treatment options; available options are also associated with toxicity, are poorly tolerated by patients, and may exhibit negative interactions with other drugs1,7,8...