Astrocytes, oligodendrocytes, lymphocytes and peripheral myeloid cells contribute to neuroinflammation in Alzheimer disease. Vascular cells become activated in Alzheimer disease and a leakiness of the blood–brain barrier is observed. A contributing role of the glymphatic system has also been described. Ne...
et al. Cytokine indices in Alzheimer’s temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein. Brain Res. 629, 245–252 (1993). Article CAS PubMed Google Scholar Sierra, A., ...
In 2015, the Italian Medicines Agency (AIFA) admitted the use of dexmedetomidine in critically ill children refractory to conventional treatment [26]. Wolf et al, in a double-blind RCT, considered efficacy and safety reporting a non-inferiority of clonidine versus midazolam [27]. Recently, ...
Loss of p53 transcriptional activity of mutant p53, and to some extent the DN effect are major drivers of the tumor phenotype (Fig.5). The loss-of-function or DN effect of wild-type p53 enhanced the viability of tumor cells, and this effect was independent of missense mutations inTP53.193T...