In addition, S100A8, S100A9, and the S100A8/A9 heterodimer participate in the complex regulation of the tumor microenvironment. Therefore, the S100A8 and S100A9 proteins are closely related to cancer biological behaviors and can be utilized as potential therapeutic targets for treatment innovation. ...
Based on this knowledge, this review will discuss potential strategies to interfere with S100A8 and S100A9 function as a novel option to develop innovative strategies for cancer prevention or therapy.doi:10.2174/187152309789839037Julia NemethPeter Angel...
Re sults:The expressi on of S100A8and S100A9wa s significantly decrea sed i n cancer tissue s both in mRNA and pro2 tein lev e l(P<0.05).The mRN A and protein ex p ression of S100A8and S100A9i n poorly differentiated tu mors was significantly lo we r co mpared to tha t ...
S100A8和S100A9主要在粒细胞、单核细胞、破骨细胞和髓系起源的早期分化细胞表达。细胞 因子LPS、TNF 、IL1等均可诱导单核细胞、内皮细胞、角质细胞和上皮细胞表达S100A8和S100A9。 原发性肿瘤分泌的VEGF-A、TGFβ和TNF 等因子也可诱导巨噬细胞和内皮细胞表达S100A8和 ...
RAGE. In addition, in situ hybridizationof S100A8 and S100A9 was done for 20 cases. An ELISA was applied to determine serum concentrations of S100A9 in cancer patients compared with healthy controls or to patients with benign prostatic hyperplasia (BPH). ...
因此,角质形成细胞在3种常见皮肤炎症损伤后响应活跃,其效应分子S100A8、S100A9作为机体的损伤相关分子密切参与UVB诱导的皮肤光损伤、变应性接触性皮炎和银屑病中炎症反应,尤其在银屑病样皮炎中响应可能更为显著。
在慢性炎症性皮肤病领域,S100A8和S100A9这对"警报素"始终充满争议——它们既是抗菌卫士,又是炎症推手。特应性皮炎(AD)患者皮肤中S100蛋白异常高表达,但不同细胞来源的A8/A9究竟如何影响疾病进程?这个问题如同迷宫般困扰着学界。更棘手的是,AD常伴随严重系统性并发症,如由IL-17A驱动的骨质流失,而金黄色葡萄球菌(...
S100A8和S100A9在妇科恶性肿瘤中的表达和临床意义
1 S100A8 和 S100A9 的结构S100 蛋白家族是一个由小分子量蛋白(10 -20KD)组成的钙结合蛋白家族,特异性表达于脊椎动物中,共有 25 名成员。S100A8/A9 由两个不同的螺旋 - 环 - 螺旋配基(EF 手型)组成,两侧为疏水区,中央为铰链区,铰链区是与靶蛋白的互动域。S100 蛋白对钙离子的亲和力较经典的钙离子感受...
S100A8andS100A9asnoveldiagnosticmarkersinhuman prostatecancedJ].ClinCancerRes,2005,11(14):5146—5152 PeterssonS,BylanderA,YhrM,eta1.S100A7(Psoriasin),highly expressedinductalcarcinomainsitu(DCIS),isregulatedbyIFN- gammainmanunaryepithelialceils.BMCCancer,2007,6(7):205 Luo,A,KongJ,HuG,eta...