Klimscha W, Horvath G, Szikszay M, Dobos I, Benedek G. Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats. Anesth. Analg. 1998; 86: 561-5.Klimscha W, Horvath G, Szikszay M, Dobos I, Benedek G....
(S)-MK-26 was initially generated as a racemic (an equal mixture of enantiomers) compound and afterwards separated by means of chiral-phase discrimination using HPLC chromatography. This physical separation method first yielded a less retained enantiomer ((S)-MK-26), and a second, stronger ...
Esketamine is a cyclohexanone derivative and S-enantiomer of racemic ketamine, with analgesic, anesthetic and antidepressant activities. Although the mechanism of action is not fully understood, upon administration, esketamine targets, non-competitively binds to, and blocks N-methyl D-aspartate (NMDA) ...
and their study in relationship to G protein signaling is mostly limited to highly non-physiologic cold detergent or alkaline extractions. Although these are the traditional means to study
of the each enantiomer was determined. Surprisingly it was observed that (−) enantiomer of DN3-27-1 possessed significantly greater activity than the (+) enantiomer in the mouse model of PCP. It is speculated that the active enantiomer is responsible for the observed activity of DN3-27-1...
A new chemical compound of ketamine active enantiomer s - (-) for the treatment of painA new chemical compound has been invented, which is characterized by the presence of an active s - (-) corresponding isomer, and the addition of other pre isomers or pharmaceutically acceptable pairings. ...
The analysis attributed (S) the absolute configuration to the less retained (S)-MK-26 and (R) absolute configuration to the more retained enantiomer (R)-MK-26. 4 of 33 3. Results 33..R1.e(sSu)-lMtsK-26 Is a Potent and Selective DAT Inhibitor 3.1. (SI)n-MviKtr-o26rIes-uapPt...