EEG-equipped Wistar rats were treated with (R)-ketamine (7.5, 15, 30 mg/kg i.p.), (S)-ketamine (7.5 and 15 mg/kg i.p.), or vehicle at the beginning of the passive phase. Frontoparietal EEG, electromyogram, and motor activity were recorded. (R)-ketamine but not ...
Furthermore, ketamine, s-ketamine, and MK 801 significantly inhibited proliferation and apoptosis.In this study, we showed the expression of the NMDA receptor type R2a in pancreatic cancer cells. The NMDA antagonists ketamine, s-ketamine, and MK 801 inhibited cell proliferation and cell death. ...
1. The purpose of this study was to demonstrate that ketamine anesthesia (100 mg/kg) induces tongue protrusions (P) in addition to retrusions (R) and swallows (S) in adult rats. 2. These linguo-pharyngeal events occur alone or combined in various sequential patterns. 3. The SPR sequence...
METHOD OF TREATING PAIN AND DEPRESSION USING A HYBRID MIXTURE OF S-KETAMINE AND R-KETAMINEA method of administering a drug formulation comprising intranasally administering a nanoparticle composition of an effective amount of hybridized esketamine racemic mil Jay, Gary ...
C57BL/6J females used as stimuli were ovariectomized under general anesthetic (xylazine/ketamine) and implanted with SILASTIC implants (Dow Corning, Midland, MI) filled with 50 µg of estradiol-benzoate (Sigma-Aldrich) in 30 µl of sesame oil. Four to five h before the tests, females...
Ketamine produces immediate antidepressant effects and has inspired research into next-generation treatments. Ketamine also has short term dissociative effects, in which individuals report altered consciousness and perceptions of themselves and their env
BACKGROUND: Ketamine blocks KATP channels in isolated cells and abolishes the cardioprotective effect of ischemic preconditioning in vitro. The authors investigated the effects of ketamine and S(+)-ketamine on ischemic preconditioning in the rabbit heart in vivo. METHODS: In 46 alpha-chloralose-anesth...
Patients who received ketamine had better sedative status (P< 0.001). None of the patients in the case group was completely awake but all of the patients in the control group were awake. The number of retching during endoscopy showed that individuals in the control group had more frequent r...
Stereoselective pharmacokinetics of ketamine: R()-Ketamine inhibits the elimination of S( )-ketamine* doi:10.1016/S0009-9236(01)06321-4Clinical Pharmacology & TherapeuticsIhmsen, HaraldGeisslinger, GerdSchüttler, Jürgen
该研究提示亚麻醉剂量s-氯胺酮在七氟醚麻醉期间对年轻和中年女性患者的苏醒时间无明显影响,诱导了活跃的前额叶脑电图表现,但术后未引起神经系统副作用。为s-氯胺酮在围手术期的应用提供了安全性证据。 研究解读 研究背景:氯胺酮由于具有镇痛、抗焦虑和抗抑郁的益处,因而在围手术期中被应用,但其在手术中使用对于七氟...