MichaëlChopin,Stephen L.Nutt, inSeminars in Cell & Developmental Biology, 2015 3.2RUNX3 RUNX3is the member of a small family of evolutionary conserved transcription factors that have essential roles in tissuehomeostasisand in the development of severalimmune celllineages[56]. In mice, lack of ...
MYCis one of the most commonly dysregulated proto-oncogenes in cancer.MYCpromotes cancer initiation and maintenance by regulating multiple biological processes, such as proliferation and stem cell function. Here, we show that developmental regulator RUNX3 targets MYC protein for rapid degradation through...
(2005a). Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823–835. Article CAS PubMed Google Scholar Kim WJ, Kim EJ, Jeong P, Quan C, Kim J, Li QL et al. (2005b). RUNX3 inactivation by point mutations and aberrant DNA methylation in ...
Katoh,Masaru - 《Cancer Biology & Therapy》 被引量: 242发表: 2007年 Mechanisms of Signal Transduction: RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells Gastric epithelial cells are less sensitive to the proapoptotic and growth inhibitory effects of transforming growth factor-...
that in non-metastasis group(P0.05).Conclusion Expression absence of RUNX3 gene is closely related with the infestation and metastasis ability of colorectal cancer,which can predicting the prognosis of the tumor,and can be used as one index for diagnosing biological action of colorectal cancer. ...
We discuss how RUNX3 serves as gatekeeper via its interactions with oncogenic signaling pathways and identify questions that may lead to new insights on cancer stem cell biology. 2. Stem Cell Regulation Is a Core Conserved RUNX Function It is interesting that the sole Runx gene in the nematode...
FISH fluorescent in-situ hybridization FL fetal liver GC gastric cancer GIT gastrointestinal tract GWAS genome-wide association study HSC hematopoietic stem cell IBD inflammatory bowel disease IHC immunohistochemistry IL-1 and IL-6 interleukins 1 and 6, respectively LOH loss of heterozygosity MNU N-met...
Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue residency, its expression is repressed in CD4+ T cells. Here, we show that, as a direct consequence of th...
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC V Selvarajan M Osato S-B Ng Leukemia (2017) Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype Paola Infante Romina Alfonsi Lucia Di ...
proliferation, apoptosis and cell invasionin vitro; the target gene of miR17-5p was identified by luciferase reporter assays, RNA Binding protein immunoprecipitation (RIP) and western blotting.In vivoanimal study was conducted to confirm the role of miR-17-5p during tumorigensis of gastric cancer....