近日,来自瑞典卡罗林斯卡研究院的Yenan T. Bryceson 教授在Immunity杂志上在线发表题为Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a的研究文章。该论文揭示人表皮CD8+CD69+CD103+CD49a+T细胞可能来源于外周CD8+CD45RA-CD62L+...
As histone modifiers are known Runx2 binding partners, we propose that Runx2 may bind CD8+ memory associated gene promotors, allowing for the maintenance of chromatin as memory cells undergo homeostatic proliferation. To further explore the function of Runx2 in T cells, we utilize a Runx2 fl/...
(B) Flow cytometry analyzing the LCMV-specific gp33+ or np396+ splenic CD8+ T cell response at day 8 post-infection (boxed). Bar graph shows the mean ± SD proportion of gp33+ or np396+ among the CD8+ T cells (n = 6). (C) Flow cytometry analyzing Granzyme B and IFN-γ ...
Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The tra
RUNX3 in Blood Cells and Cancer RUNX3was originally cloned due to its high homology toRUNX1andRUNX2. RUNX3 is involved in the development of CD8cytotoxic T cells(Sato et al., 2005). A blood cell-specific conditionalknockout mousemodel ofRunx3has been described (Wang et al., 2013). The...
Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The tra
Runx2 is a transcription factor involved in melanoma cell migration and proliferation. Here, we extended the analysis of Runt domain of Runx2 in melanoma cells to deepen understanding of the underlying mechanisms. By the CRISPR/Cas9 system we generated t
similar to the role of this cytokine in breast cancer bone metastasis [72]. CSF2 production by tumor cells may also contribute to accumulation of macrophages, inflammatory T cells, and cytokines [73,74] that exacerbate morbidity and mortality [75]. Two additional Runx2-up-regulated genes associ...
TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis. Arthritis Res Ther. 2020;22(1):149. Article CAS PubMed PubMed Central Google Scholar Hung BP, Hutton DL, Kozielski KL, Bishop CJ, ...
While Runx1 and Runx3 have well known roles in the development of CD8 T cells, the function of Runx2 is not well established. To further explore the function of Runx2, our lab utilizes a model of retroviral overexpression and CRISPR knockout of Runx proteins in OT-1 CD8 T cells. ...