Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-like pr
Snail, Slug, and Twist are transcription factors that respond to extracellular triggers of EMT by executing cellular programs suppressing epithelial-specific proteins including E-cadherin and ZO-1 and inducing mesenchymal-specific proteins including N-cadherin and α-smooth muscle actin (α-SMA)19,20...
Purpose Chronic kidney disease (CKD) has become a global public health problem and accompanied by renal fibrosis. MiR-194, a tumor suppressor gene, has been previously reported to be associated with the pathogenesis of tissue fibrosis. However, the role of miR-194 in the pathogenesis of renal ...
with AML-M4Eo.4 This inversion generates a chimeric gene CBFb–MYH11, which encodes a fusion protein between CBFb and smooth muscle myosin heavy chain (SMMHC/MYH11).5–8 Heterozygous Cbfb-Myh11 knock-in mice are embryonic lethal, with definitive hematopoiesis blocked at the stem-cell level....
(IL-6), and matrix metalloproteinase-9 (MMP-9). The review covers studies detailing RUNX1's impact on endothelial cell damage, smooth muscle cell phenotypic changes, and extracellular matrix degradation. Potential therapeutic strategies targeting RUNX1 are discussed, highlighting the need for further...
Runx1 vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivodoi:10.1038/s41467-024-44913-zHematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smo...
Macrophages co-cultured with adipocytes overexpressing RUNX1 exhibited enhanced CD86 expression, while vascular smooth muscle cells co-cultured with these adipocytes showed reduced α-SMA expression. In human samples, there was an increase in both RUNX1 and MMP-2 expression levels, accompanied by a ...
The two subunits of core binding factor (Runx1 and CBFβ) play critical roles in hematopoiesis and are frequent targets of chromosomal translocations found in leukemia. The binding of the CBFβ-smooth muscle myosin heavy chain (SMMHC) fusion protein to Runx1 is essential for leukemogenesis, ...
RUNX1 and CBF尾 form a transcription factor dimer that regulates normal hematopoiesis and leukemogenesis. Inversion of chromosome 16 (inv(16)) is one of the most common mutations in acute myeloid leukemia (AML), fusing CBF尾 with the gene encoding smooth muscle myosin heavy chain (MYH11). ...
RUNX1 function in hematopoiesis is determined by cell context-specific interactions with DNA, other TFs, and co-factors. The characterizing domain of RUNX1 is the N-terminal Runt homology domain (RHD), a conserved DNA binding domain necessary both for the recognition of the DNA consensus sequenc...