本系列将简单梳理十条经典癌症相关信号通路1,包括1) RTK/RAS通路;2) Wnt通路;3) Hippo通路;4) Nrf2通路;5) TGFβ通路;6) Myc通路;7) Notch通路;8) PI3K通路;9) p53通路;10)细胞周期通路。 图一. 经典癌症相关信号通路1 RTK...
DDR1在某些非恶性肿瘤细胞中起着抑制增殖与生长的作用,如原代鼠系膜细胞,但是尚未有文献报道DDR1能抑制恶性肿瘤细胞的增殖与生长。研究表明,在人乳腺癌和结肠癌中,DDR1主要是通过激活Ras/Raf/ERK和PI3K/Akt通路,从而上调抗凋亡蛋白Bcl-xL和使得细胞在基因毒性应激状态下存活下来 [5, 16-17]。 5.2 DDR1与肿瘤的...
PI3K/AKT pathwayCELL survivalCELL migrationP53 proteinXENOGRAFTSThis article discusses the potential anti-cancer effects of evodiamine, a natural compound derived from Evodiae fructus, on colorectal cancer (CRC). The study found that evodiamine inhibited the growth and induced cell death in C...
二聚化后,RTK蛋白构象发生改变,ATP可以进入其中一个RTK的催化位点,并发挥激酶活性催化另一个RTK磷酸化。然后激活MAPK、PI3K/AKT和JAK/STAT等信号通路,在细胞增殖、存活、迁移和血管生成等功能中发挥重要作用。 RTKs与肿瘤关系(源自参考文献:doi: 10.103...
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this pathway is implicated in the development and
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this pathway is implicated in the development and progression of cancers. Receptor tyrosine kinases...
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this pathway is implicated in the development and
(PI3K)/Akt and mammalian target of rapamycin (mTOR) pathways, frequently manifest irregularities within the subset of TNBC, closely aligned with the dysregulation of RTKs. Vigorous exploration is underway concerning targeted therapeutic interventions directed towards these oncogenic pathways, and promising ...
Prostate cancer lineage plasticity is a key driver in the transition to neuroendocrine prostate cancer (NEPC), and the RTK/RAS signaling pathway is a well-established cancer pathway. Nevertheless, the comprehensive link between the RTK/RAS signaling pathway and lineage plasticity has received limited ...
MEG3 induces autophagy by upregulation of sirtuin 7 and inhibition on the PI3K/AKT/mTOR pathway in glioma cells33. MEG3 binds with miR-378 to inhibit the protective influence of miR-378 against neuronal autophagy and neurological functional impairment in ischemic stroke34. To explore the ...