The results showed that AS promoted cell viability, decreased ROS production and mitigated mitochondrial damage in Dox-exposed H9C2 cells. Importantly, AS also modulated the Silent information regulator 1 (SIRT1)/Forkhead box O3a (FOXO3a)/Manganese superoxide dismutase (MnSOD) pathway, indica...
et al. Mitochondria ROS and mitophagy in acute kidney injury.Autophagy.2022;1-14.Tang C, Cai J, Yin XM, et al. Mitochondrial quality control in kidney injury and repair.Nat Rev Nephrol. 2021;17(5):299-318.Wang Y, Cai J, Tang C, et al. Mitophagy in Acute Kidney Injury and Kidney...
and mitochondrial DNA damage(the latter a previously described UVR biomarker in skin).Recent work associates bioenergy production and oxidative stress with pigment production thereby providing another additional potential avenue for targeted anti-ageing intervention in skin.This new data supporting the ...
WGX50可改善DOX诱导的MMP失衡(图 6A)、TOM20 水平下降(图 6B)、ATP 产量(图 6C)及线粒体ROS产生(图 6D)、GSH/GSSG 比率下降(图 6E)、Fe2+累积(图 6F)、脂质过氧化(图 6G),表现出强大的抗氧化能力。 R7: WGX50 has a strong effect on reducing mitochondrial damage and inhibiting ferroptosis 作者进...
Rationale Mitochondrial dysfunction contributes to greater susceptibility to injury from superimposed disease in the aged heart. Aging decreases complex III activity and increases ROS production from complex III. Oxidative stress from mitochondria can trigger endoplasmic reticulum (ER) stress. Objective To ...
Byproducts of normal mitochondrial metabolism and include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief (mPTP) openings play an important physiological role maintaining healthy mitochondria . Adaptive...
[42]. The mitochondrial damage alters its function, decreasing ATP production and increasing ROS levels, resulting in a positive feedback process that amplifies its damage [43]. In contrast, uncoupling proteins (UCPs) decrease the membrane potential of mitochondria in oxidative phosphorylation, which...
effect against oxidative injury in muscle cells has not been reported.#The current study aimed to investigate whether hesperidin can prevent oxidative damage in C2C12 murine myoblasts.#Hesperidin was able to inhibit cytotoxicity while blocking hydrogen peroxide (H2O2) H2O2-induced DNA damage and ...
However, when the formation and clearance of ROS lose its balance, excessive ROS may cause tissue damage. In the research of heart failure, people found that ROS could affect the formation and development of heart failure in many pass ways.Here we are going to discuss those pass waysand ...
Rapamycin, administered in combination with inhibitors of HSP90, causes mitochondrial damage with accompanying oxidative stress and autophagy and reduces tumor growth in RAS-dependent tumors120. ROS and necroptosis (type III programmed cell death) ROS are also able to induce necrosis, which was ...