In light of the strong connections between ROS and cardiac disease, there has been intense interest in deciphering the mechanisms regulating cardiac ROS production and detoxification, as well as in developing therapies to limit ROS production and enhance ROS detoxification as a means to ameliorate card...
Furthermore, the results using inhibitors of each signaling pathway demonstrated that ROS mediated the compression-induced ER stress and mitochondrial dysfunction in cortical neurons. In conclusion, our results demonstrated that compression induced apoptosis in primary cultured cortical neurons, which was ...
Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities Sivitz WI, Yorek MA (2010) Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid ... WI Sivitz,MA Yorek 被引...
Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate the sp...
Indeed, mitochondria are the most important source of ROS in most of the mammalian cells [43]. ROS produced in mitochondria during OXPHOS process primarily triggered mitochondrial dysfunction by interacting with mitochondrial and cellular components such as DNA, proteins, lipids, and other molecules [...
Studies have indicated the effect of mitochondrial dysfunction on skeletal muscle atrophy. For example, in cisplatin-induced muscle atrophy, mitochondrial mass, membrane potential and reactive oxygen species (ROS) levels are abnormal. Therefore, reducing ROS production, rather than promoting ATP production...
Cellular metabolism interconnects the nine hallmarks of ageing, and deregulation of energy metabolism by environmental variations is an essential process leading to mitochondrial dysfunction during ageing. A better understanding of mitochondrial dysfunction during ageing and age-related metabolic diseases will ...
Mitochondria are considered the powerhouse of the cell being the major site of ATP production but in addition to this function they also regulate ROS production and inhibition, calcium handling and apoptosis. Previous studies have reported a downregulation in the levels of superoxide dismutase 2 (SOD...
Mitochondrial dysfunction and the production of reactive oxygen and nitrogen species (ROS, RNS) are common denominators of ischemia/reperfusion damage, as well as of many neuro-muscular dystrophies and neurodegenerative or other age-related disorders [107], [108], [109], [110]. Their pathological...
Mitochondrial ROS can originate from multiple reactions in the TCA cycle and/or in the respiratory chain. Several in vitro studies suggested a link between elevated A levels, mitochondrial dysfunction, and oxidative stress, all factors that contribute to AD pathogenesis. Moreover, ...