Proteins of the S100 family belong to the EF-hand superfamily, and there are EF-hand domains at the N-terminal and the C-terminal [5]. In cells, most S100 proteins exist in the form of homologous dimers, whereas a few form heterodimers, trimers, and tetramers. They can exist in the...
aeffect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs 这些蛋白质的作用在细胞增殖和一个可能的消极角色在对重的基于金属的和非重的基于金属的药物的抵抗[translate]...
aggregation in the presence of biomolecular condensates: increasing the local concentration of proteins, providing a distinct chemical microenvironment, introducing an interface wherein proteins can localize, changing the energy landscape of aggregation pathways, and the presence of chaperones in condensates....
under the stimulation of local mechanical forces and of transforming growth factor b1 (TGFβ1), produced by infiltrated macrophages or local cells, in conjunction with the ectodomain A (ED-A) sequence of cellular fibronectin (FN) (Tomasek et al., Nat Rev Mol Cell Biol 3:349–363, 2002)....
Upon accumulation of misfolded proteins, IRE1α homomultimerizes and transautophosphorylates to activate its endoribonuclease activity that removes an intron in XBP1 mRNA. Spliced XBP1 (XBP1s) mRNA encodes a transcription factor that translocates into the nucleus to activate genes that encode chaperones...
For its part, the PDIA6 gene encodes for a disulfide isomerase in the ER, responsible for formation, reduction and isomerization of disulfide bonds in proteins. Therefore it is thought to play a role in the folding of proteins with disulfide bonds. The last one, PDIA5, encodes member 5 of...
We recently reported that in the absence of JunD protein in PCa cells, cell proliferation is inhibited along with a significant decrease in the levels of proteins involved in cell cycle regulation including c-MYC [29]. Furthermore, the over-expression of JunD significantly increased cell ...
a series of therapeutic methods targeting lysosomal proteins and processes have been developed from bench to bedside. In a word, present researches corroborate lysosomes to be pivotal organelles for understanding pathology of atherosclerosis, neurodegenerative diseases, autoimmune disorders, pancreatitis, and ...
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice 2008, Epilepsy Research Citation Excerpt : Although many of these effects are seen with muscarinic and mGluR activation as well, they do not always share a common PKC-relevant mechanism (e.g. Sim et al., ...
Protein palmitoylation has been implicated in the clustering of a number of proteins into a specific lipid microdomain “raft” enriched in cholesterol and sphingomyelin33. Cholesterol is suggested to be enriched at the TGN, and cholesterol together with sphingomyelin generated by sphingomyelin syn...