H. 2005. Proteins and the flow of information in cellular function. In Molecular Imaging FRET Microscopy and Spectroscopy. A. Periasamy and R. N. Day, editors. Oxford University Press, New York.Proteins and the flow of information in cellular function. Kretsinger R H. Molecular Imaging FRET...
A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30...
We here describe PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method, assessed biologically and statistically, enabled us to classify 11% of the Saccharomyces
Does USP32 have any other functions among many types of tumors? How does USP32, a target for many cancer therapies, specifically regulate the content and function of relevant proteins through deubiquitination? USP32 has a regulatory effect on a wide range of tumors, so it is possible to ...
They have also been used to investigate the role of these enzymes, often in combination with other DNA polymerases, in replication past various lesions, leading to proposals concerning the in vivo function of the enzymes. It is likely, however, that such reactions lack important factors present ...
Nucleocytoplasmic transport of proteins occurs through pores embedded in the nuclear envelope. Recent studies have defined the cytoplasmic factors required for signal-mediated import of nuclear proteins. Considerable progress has been made in understanding the mechanism of nuclear export of proteins by the...
The activity of PARP family members, such as PARP1 and PARP2, is tied to cellular signalling pathways, and through poly(ADP-ribosyl)ation (PARylation) they ultimately promote changes in gene expression, RNA and protein abundance, and the location and activity of proteins that mediate signalling ...
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy in the form of heat. These thermogenic fat cells were originally considered to function solely in heat generation through the action of the mitochondrial protein uncoupling protein 1 (UCP1). In recent years, sign...
The Landscape and Perspectives of the Human Gut Metaproteomics Zhongzhi Sun, Zhibin Ning, Daniel FigeysMay 2024 Article 100763 View PDF Article preview select article Proteomics Impact on Cell Biology to Resolve Cell Structure and Function Review articleOpen access Proteomics Impact on Cell Biology to ...
These proteins form part of a signaling network that is disrupted in most, if not all, cancer cells. Recent evidence suggests that PDCD5 participates in immune regulation by promoting regulatory T cell function via the PDCD5–TIP60–FOXP3 pathway. The stability and expression of PDCD5 are ...