DNA- and RNA-binding proteins (DRBPs) constitute a significant fraction of cellular proteins and have important roles in cells. Their functions include control of transcription and translation, DNA repair, splicing, apoptosis and mediating stress responses. ...
The unique architecture and function of cellulose-interacting proteins in oomycetes revealed by genomic and structural analyses Mathieu Larroque, Roland Barriot, Arnaud Bottin, Annick Barre, Pierre Rougé, Bernard Dumas & Elodie Gaulin BMC Genomics volume 13, Article number: 605 (2012) Ci...
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial functions in bioenergetics, metabolism and signalling and have been associated with numerous diseases. Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. ...
Sparks of function by de novo protein design Alexander E. Chu, Tianyu Lu & Po-Ssu Huang Nat Biotechnol 42, 203–215 (2024) • poster A Survey of Generative AI for De Novo Drug Design: New Frontiers in Molecule and Protein Generation Xiangru Tang, Howard Dai, Elizabeth Knight, Fang Wu...
Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. In the present study we used an adoptive transfer model with athymic nude mice to characterize the T cells involved in initiating and mediating skin allogr... Rosenberg,A. S. -...
function of multiple cells or tissues. The process of cell signaling imposes many demands on the proteins that comprise these pathways, including the abilities to form active and inactive states, and to engage in multiple protein interactions. Furthermore, successful signaling often requires amplifying...
(CAR) expression following transduction is a critical step in the production of CAR-T and CAR-NK cells for cancer immunotherapy. To simplify CAR detection, R&D SystemsTMfluorescent-labeled proteins bind directly to single chain variable fragment (scFv) CAR T cells. Have confidence in your results...
Likewise, IGF2BPs modulate cell polarization, adhesion and migration in tumor-derived cells. Moreover, they are highly associated with cancer metastasis and the expression of oncogenic factors (KRAS, MYC and MDR1). However, a pro-metastatic role of IGF2BPs remains controversial due to the ...
While leukemic blasts often exhibit immunophenotypes distinct from normal cells, with some surface markers even serving as therapeutic targets5, immunotypes are only weakly prognostic. Genotypes, in contrast, are more informative on the disease course, which suggests a weak correspondence between these ...
et al. The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep. 12, 581–586 (2011). Article CAS PubMed PubMed Central Google Scholar Leung, A. K. et al. Genome-wide identification of AGO2 binding sites from mouse embryonic stem cells ...