Although the chemically-defined 2i/LIF medium has provided solutions to some of these challenges, prolonged culturing of these cells, especially female ESCs, raises concerns related to genome integrity. This review discusses the pivotal role of lipids in genome stability and pluripotency of stem ...
the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions of cells and cell membranes. An enzyme known as ELOVL6 elongates chains of fatty acids and is important in several cellular metabolic processes. However, the relationship...
There is emerging evidence that lipids and lipid metabolism are essential for cancer growth. In hepatocellular carcinoma a decline of apoptotic lipids like ceramides is supposed to hinder death of cancer cells. Accumulation of saturated fats may protect the cells from oxidative stress. Enhanced lipogene...
By using RNA-sequencing analysis and HIF-1伪 knockdown in DPCs, we found that HIF-1伪 is a potential candidate that governs lipid-reinforced upregulation of trichogenic genes. Finally, we assessed the hair growth-promoting effects of lipids using in vitro hair follicle organoids and found that...
cells [125]. In addition to affecting proliferation of CSCs, uptake of palmitic acid via CD36 also specifically activates the metastatic potential of CD44brightoral squamous cell carcinoma (OSCC) metastasis-initiating cells [126], highlighting the central role of lipids uptake in fueling tumor ...
The differences in lipid compositions between yeastlike cells and mycelium; the role of the structural and regulatory lipids, fatty acids, and their derivatives in morphological transformation of fungi; and the involvement of lipids in signal transduction and host-pathogen interactions are discussed. ...
interpreted as the protein interacting with the lipids in the monolayer and becoming embedded in it. Both ATG3 and the mutant were able to insert into these lipid monolayers extended at an initial surface pressure ≥23 mN/m (Fig.2B), i.e. above the maximum change in surface pressure ...
Cancer cells display sensitivity to ablation of fatty acid synthesis possibly as a result of diminished capacity to synthesize complex lipids involved in signaling or growth pathways. Evidence has accrued that phosphatidylcholine, the major phospholipid component of eukaryotic membranes, as well as choline...
In chronic obstructive pulmonary disease (COPD) apoptotic bronchial epithelial cells are increased, and their phagocytosis by alveolar macrophages (AM) is decreased alongside bacterial phagocytosis. Epithelial cellular lipids, including those exposed on
Nervous system functions depend on the neuronal networks formed in part by axons. During development, axons migrate long distances to reach particular targets. A variety of environmental cues regulate and guide axon elongation by binding to relevant rece