At the subcellular level, it occurs in phagocytosis, pinocytosis, the entry of parasites into cells, virus entry into and exit from cells, and secretion by exocytosis; lysosomal digestion is also totally dependent on membrane fusion. The role of lipids in membrane fusion springs from the ...
Most integral membrane proteins are cotranslationally inserted into the lipid bilayer. In prokaryotes, membrane insertion of the nascent chain takes place
Oligomerization of membrane proteins in response to lipid binding has a critical role in many cell-signalling pathways1 but is often difficult to define2 or predict3. Here we report the development of a mass spectrometry platform to determine simultaneously the presence of interfacial lipids and olig...
In hepatocellular carcinoma a decline of apoptotic lipids like ceramides is supposed to hinder death of cancer cells. Accumulation of saturated fats may protect the cells from oxidative stress. Enhanced lipogenesis is essential for cell proliferation. Disturbed lipid metabolism was also described in ...
The molecular mechanisms engaged in these complex processes in the formation of intracellular transporters have been studied in many systems, such as semi-intact cells, cell-free systems, and yeast mutants, but only limited progress has been achieved in understanding vesicle biogenesis and vesicle-...
What is the role of the cell membrane?Cell membrane:The cell is composed of various components that provide it with functional and structural characteristics. All the organelles are contained inside the cell, suspended in the cytoplasm and outlined by a double-layered structure known as the cell ...
In summary, lipid signalling is intricately involved in extracellular vesicle-mediated cell-to-cell communication. The lipid composition of EVs influences their biogenesis, cargo sorting, interactions with target cells, and functional effects on recipient cells. Understanding the role of lipids in EV-...
In eukaryotic cells, the distribution of lipids on biological membranes is asymmetric [1]. Glycosphingolipid, sphingomyelin, and phosphatidylcholine (PtdCho) mainly distribute on the outer leaflet, while aminophospholipids such as phosphatidylethanolamine (PtdEtn) and phosphatidylserine (PtdSer) mostly...
Both C99 and APP are able to protect themselves from cleavage by forming homodimers, a protein composed of two polypeptide chains that are identical. The interaction between C99 molecules is regulated by lipids that make up the membrane in which the protein sits. ...
The plasma membrane and the concept of interleaflet coupling The plasma membrane is known to have an asymmetric distribution of lipids between the two leaflets. Almost all sphingolipids and phosphatidylcholine (PC), a phospholipid with a choline headgroup, are present in the outer leaflet, whereas...