Extracellular vesicles: lipids as key components of their biogenesis and functions. J Lipid Res. 2018;59 (8):1316-1324.Record M, Silvente-Poirot S, Poirot MA. Extracellular vesicles: lipids as key components of their biogenesis and functions. J Lipid Res, 2018, 59(8): 1316-1324....
Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat—Store 'em Up or Burn 'em Down Lipid droplets (LDs) and peroxisomes are central players in cellular lipid homeostasis: some of their main functions are to control the metabolic flux and ... SD Kohl...
By the nature of the reaction, PAP activity controls the cellular concentrations of these two important lipid mediators, playing a role in lipid signaling. Thus, the regulation of PAP activity may govern whether cells make storage lipids or membrane phospholipids, determine the pathways by which ...
Moreover, the potential functions of key DELMRGs were assessed using gene set enrichment analysis (GSEA). Furthermore, a potential transcription factor (TF)-miRNA regulatory network of the key DELMRGs was predicted. Finally, based on the DELMRGs, AD samples were divided into two subclusters, ...
Cancer cells are lipid-rich under normoxia and hypoxia, leading to the increased generation of a cellular organelle, the lipid droplet (LD). In recent years, the LD-mediated stress response mechanisms of cancer cells have been revealed. This review focuses on the production and functions of LDs...
Lipidomic approaches in cancer research have created new opportunities for understanding the functions and mechanisms of lipids in cancer cells. Lipidomic analysis of phospholipids in human mammary epithelial cells versus breast cancer cells has previously indicated that an increase in cellular PC O-16:...
Abstract Lipid flippases (P4 ATPases) are active transporters that catalyse the translocation of lipids between the two sides of the biological membranes in the secretory pathway. This activity modulates biological membrane properties, contributes to vesicle formation, and is the trigger for lipid sign...
Causes sequestration of substantial amounts of lipids present in tissues affected by obesity by macrophages known as foam cells, which fuel the metabolic consequences of unhealthy obesity and unhealthy ageing in general. Activates macrophages and other innate immune cell types, which are enriched in un...
Apolipoprotein E deficiency in mice leads to the development of atherosclerosis and re-expression of the protein reduces the extent of the disease. This review presents evidence for the potent anti-atherogenic action of apolipoprotein E and describes our current understanding of its multiple functions ...
While this feed-forward control helps to ensure that ATP levels do not fall during times of high demand, it also increases the production of damaging reactive oxygen species (ROS) and basal mitochondrial oxidant stress. ROS and mitochondrial oxidant stress damages lipids, proteins and DNA [33]....