Extracellular vesicles: lipids as key components of their biogenesis and functions. J Lipid Res, 2018, 59(8): 1316-1324.Record M, Silvente-Poirot S, Poirot M, Wakelam MJO. Extracellular vesicles: lipids as key components of their biogenesis and functions. J Lipid Res. 2018;59(8):1316-...
Moreover, the potential functions of key DELMRGs were assessed using gene set enrichment analysis (GSEA). Furthermore, a potential transcription factor (TF)-miRNA regulatory network of the key DELMRGs was predicted. Finally, based on the DELMRGs, AD samples were divided into two subclusters, ...
Of all the diverse functions ascribed to sirtuins, perhaps the one common theme is their striking ability to influence key aspects of mammalian metabolism. As the storage and utilization of lipids play an important role in human health and disease, this review will focus on the mechanisms by ...
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Causes sequestration of substantial amounts of lipids present in tissues affected by obesity by macrophages known as foam cells, which fuel the metabolic consequences of unhealthy obesity and unhealthy ageing in general. Activates macrophages and other innate immune cell types, which are enriched in un...
Further research is essential to support these results and verify the underlying biological functions of key amino acid metabolites through large-scale and mechanistic studies.Data availability The data presented in this study are available on request from the corresponding author. The data are not ...
Lipidomic approaches in cancer research have created new opportunities for understanding the functions and mechanisms of lipids in cancer cells. Lipidomic analysis of phospholipids in human mammary epithelial cells versus breast cancer cells has previously indicated that an increase in cellular PC O-16:...
In MM134 LTED cells, the most enriched pathways were related to activation of immune functions and metabolism. Intriguingly, the enriched metabolic pathways were all related to lipid synthesis and lipid metabolism, such as "Ke- togenesis" and "Superpathway of Cholesterol Biosynthesis" (indicated ...
Considering that IDR4 is partly encoded by exon 18 and 19, which are missing in the PIEZO2 splice variants that are expressed in the lung and the bladder39, it is nevertheless tempting to speculate that IDR4 might contribute to the tissue-specific functions of PIEZO2. Regarding the role of...
et al. Comparative transcriptome analysis reveals different functions of Kandelia obovata superoxide dismutases in regulation of cadmium translocation. Sci. Total Environ. 771, 144922 (2021). Article ADS CAS PubMed Google Scholar Chen, H. et al. Metabolomics and proteomics reveal the toxicological ...