Stretch-activated channels (SACs) are ion channels found in cell membranes that open or close in response to mechanical deformation or stretching of the membrane [31]. SACs could be subdivided by their ion selectivity into K+-selective (SACK) and cation non-selective channels (SACNS). Recently...
Ion channels, the "gatekeepers" of ions across the cell membrane, contribute to numerous cellular processes such as cell volume regulation, membrane potential, signal transduction, and cell proliferation. More than 400 genes encoding ion channels account for ∼1.5% of the human genome, and they ...
Stroke is one of the major causes of mortality and morbidity worldwide, yet novel therapeutic treatments for this condition are lacking. This review focuses on the roles of the transient receptor potential melastatin 2 (TRPM2) ion channels in cellular damage following hypoxia-ischemia and their pot...
The effect of the administration of pertussis toxin as well as modulators of different subtypes of K+ channels on the antinociception induced by the H1-antihistamines pyrilamine, diphenhydramine and promethazine was evaluated in the mouse hot plate test. Pretreatment with pertussis toxin (0.25 μg/...
This review focuses on the roles of the transient receptor potential melastatin 2 (TRPM2) ion channels in cellular damage following hypoxia-ischemia and their potential as a future therapeutic target for stroke. Here, we highlight the complex molecular signaling that takes place in neurons, glial ...
As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC ...
Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop
In the course of their development, plants have had to face a wide range of potential pathogens, including viral, bacterial, fungal and oomycete pathogens. Plants, unlike animals, which have specialized defender cells and an adaptive immune system, have an innate immunity of each cell and ...
Acid-sensitive ion channels, such as amiloride-sensitive cation channel (ACCN), transient receptor potential vanilloid-1 (TRPV1), and T-cell death-associated gene 8 (TDAG8) are highly related to the expression of fear and are expressed in several regions of the brain. These molecules can de...
Fig. 2: The mechanisms of H2S function in the organism. Promotion or inhibition of signaling pathways, post-translational modification of proteins, activation or shutdown of ion channels, and participation in mitochondrial metabolism. Akt protein kinase B, ERK extracellular signal-regulated kinase, JN...