Interplay between various ion channels in the membrane of cardiomyocytes is responsible for depolarization and repolarization of the heart cells, whereas cell-to-cell coupling, mediated by gap junction proteins, is involved in propagation of the action potential through the heart. In this chapter, ...
The difference and the works are transmitted from one cell to the other through the formation of a synapse. The cells have a chemical composition and function through the action potential of all the cells.Answer and Explanation: Become a member and unlock all Study Answers Start...
Editorial: Transient receptor potential (TRP) ion channels in non-excitable cells Non-excitable cells have no voltage-gated sodium or calcium channels and are unable to generate action potentials in response to depolarizing stimuli. As a... M Nazrolu,BM Radu,D Cucu - 《Frontiers in Physiology》...
CNBD-channels and Kv-like channels are involved in many essential physiological processes in different cell types of metazoans. The opening of Kvchannels during membrane depolarization ensures the repolarization phase of the action potential in excitable cells12. HCN channels play a crucial role in th...
The TREK K2P channel activity is dynamically regulated by protein kinase-dependent signaling pathways involved in the development of various human diseases. Here, the authors report how phosphorylation at the proximal C-terminus induces allosteric deactivation of the selectivity filter gate. Berke Türkay...
Answer to: What is thought to cause the sodium channels that initiate an action potential to be inactivated for a brief time after being open for...
Potassium channels are widely distributed in a variety of healthy and cancer cells. They are involved in physiological cell proliferation and neoplastic growth as well as tumor progression and malignancy. In fact, it has been increasingly documented that K+ channels have an oncogenic potential [5],...
In this study, we explored the possibility that two-pore domain potassium (K2P) channels are sufficient to support action potential (AP) generation in the absence of conventional voltage-gated potassium (KV) channels. Hodgkin–Huxley parameters were used to mimic the presence of voltage-gated sodi...
TRP channels in neurogastroenterology: opportunities for therapeutic intervention The members of the superfamily of transient receptor potential (TRP) cation channels are involved in a plethora of cellular functions. During the last deca... W Boesmans,G Owsianik,J Tack,... - 《British Journal of ...
Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channels. Nature [Internet] 2005 [cited 2014 Mar 3]; 436:559-62. Available from: http://www.ncbi.nlm.nih. gov/pubmed/16049489; PMID:16049489; http://dx. doi.org/10.1038/nature03834...