action potentialmodeling and simulationNa+ channeldelayed rectifier K+ channelBased on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their ...
Action Potential and Ion Channel Effects on Neurophysiology Journal of neurology & neurophysiologyPatrik Baillet
Excitable cells use a variety of different ion channels to fashion their hallmark electrical signal, the action potential. Advances in molecular electrophysiology have led to the identification of more ion-channel genes than there are ... DC Johns,UC Hoppe,E Marbán,... - Humana Press 被引量:...
Thus, to create a realistic electrical circuit analogue to the biological neuron, one should emulate the conductance of the sodium channel, which shows a fast activation and inactivation, and the potassium channel, which activates after a certain delay. Simple leaky integrate-and-fire model neurons...
Animal toxins can modulate action potentials and are important leads for therapeutics. Here, the authors use cryo-EM to show the interaction of the tarantula venom peptide Protoxin-I with a human voltage-gated sodium channel implicated in pain ...
Effect of Sensor Domain Mutations on the Properties of Voltage-Gated Ion Channels: Molecular Dynamics Studies of the Potassium Channel Kv1.2 The effects on the structural and functional properties of the Kv1.2 voltage-gated ion channel, caused by selective mutation of voltage sensor domain resid......
Mitochondria play a crucial role in numerous cellular functions. The proper functioning of mitochondria heavily relies on the tightly controlled transport of ions across their membranes. Consequently, the activity of mitochondrial ion channels, which imp
Voltage-gated Na + channels are dynamic transmembrane proteins responsible for the rising phase of the action potential in excitable membranes. Local anes... C Nau,GK Wang - 《Journal of Membrane Biology》 被引量: 301发表: 2004年 Phasic ion channel blockade: A kinetic model and parameter estim...
The US-mediated currents exhibited the expected K+reversal potential (Fig. 4left, dark brown;Fig. 5), showed the characteristic voltage dependence of TREK-1 mechanosensitive currents (Fig. 4left, dark brown), were greatly reduced following the application of the BaCl2K+channel blocker (Fig. 4...
Molecular and electrical remodeling of ion channels determining action potential duration has been proposed as a major mechanism in chronic atrial fibrilla... JB Grammer,X Zeng,RF Bosch,... - 《Basic Research in Cardiology》 被引量: 254发表: 2001年 Atrial L-type Ca-channel, β-adrenoreceptor...