The role of insulin in the pathogenesis of hypertension was explored in normal men and male patients with impaired glucose-tolerance. They were classified as normal (n = 94), borderline (n=164), impaired tolerance (IGT, n = 104), or diabetes mellitus (n = 100) according to their response...
4, 2005 The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Al heimer's Disease Claude Messier and Kevin Teutenberg School ofPsychology, University ofOttawa, Ottawa, Ontario, Canada K1N 6N5 ABSTRACT Most brain insulin comes from the p...
Mechanistic insights into insulin resistance in the genetic era the critical role of adipose tissue in human metabolic health and the meaning and importance of 'partial' insulin resistance for major human disease.doi... VER Parker,DB Savage,S O’Rahilly,... - 《Diabetic Medicine》 被引量: 76...
In 1982, the National Institutes of Health initiated a comprehensive study of the pathogenesis of type 2 diabetes among the Pima Indians of Arizona, a population with an exceptionally high prevalence of the disease. By the year 2000, insulin sensitivity (two-step hyperinsulinemic glucose clamp) ...
Together, they are responsible for the incretin effect: a two- to three-fold higher insulin secretory response to oral as compared to intravenous glucose administration. In subjects with type 2 diabetes, this incretin effect is diminished or no longer present. This is the consequence of ...
Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study Formula milk-fed infants show faster rates of growth and weight gain than do breastfed infants, and they have higher concentrations of insulin-like growth ...
R. The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways. J. Biol. Chem. 272, 6653–6662 (1997). 33. Park, I.-H. & Chen, J. Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube...
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic β-cells. Diabetes. 1997;46:1087–93. Article CAS PubMed Google Scholar Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, et al. The pancreatic β cell is a key site...
These data underscore the importance of zinc nutrition, particularly in underdeveloped countries where the risk of infection is heightened because of poor sanitation, public health, and vaccination strategies (5). This review focuses on the role of zinc as an essential micronutrient that is required ...
Sex differences in the control of sex-hormone-binding globulin in the elderly: role of insulin-like growth factor-I and insulin 喜欢 0 阅读量: 55 作者:P Lecomte,N Lecureuil,M Lecureuil,Y Lemonnier,N Mariotte,C Valat,M. Garrigue