To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life.Prospective, population based study.Populations of Kuopio and Joensuu, eastern Finland.Participants were derived from random, population based samples previously st...
In addition, nutritional caloric or proteic deficit may add to the effects of GH, age and other factors in decreasing IGF-I synthesis and therefore further contribute to the development of primary osteoporosis. 展开 关键词: IGF-I IGF-BP osteoporosis PTH calcitriol bone mineral density body mass...
Studies show that intensive glycaemic control could significantly reduce the risk of diabetic complications. With the increasing number of diabetic patients under primary care indicated for insulin, family physicians will play a pivotal role in prescribing it in their setting. The initiation and ...
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Alzheimer's disease; aberrant signalling occurs in diverse ...
In order to study the relationship of insulin resistance with cerebral hemorrhage and cerebral infarction, the ratio of serum insulin with blood glucose (I/G) in 41 normotensive cerebral hemorrhage patients (NTCH), 51 normotensive cerebral infarction patietns (NTCT) and 39 control subjects was mea...
A critical step in ovarian biology is the transition of the developmentally arrested primordial follicle to the growing primary follicle. The current study utilizes a rat ovarian organ culture system to investigate the role of insulin and insulin-like growth factor-1 (IGF-1) in this process. Four...
Insulin resistance in uremia. Characterization of insulin action, binding, and processing in isolated hepatocytes from chronic uremic rats. We have developed a model in the rat that leads to a predictable degree of severe uremia to study the role of the liver in the insulin-resistant state of ...
It is known that some metabolic disturbances may modify the progression of renal disease including primary glomerulonephritis, but the role of purines in this process is still unknown. To investigate this, 13 untreated patients with primary glomerulonephritis were followed up for a mean of 17.6 month...
Insulin is the central regulator of metabolism and is necessary for storing energy as fat efficiently. Mitochondria are primary sites of energy consumption of most cells. Increased plasma insulin level and mitochondrial dysfunction are features of insulin resistance. The exact role of insulin in regulat...
Role of insulin-mediated antinatriuresis in sodium homeostasis and hypertension. Hypertension. 2018;72:1255–62. Article CAS PubMed Google Scholar Rucker AJ, Rudemiller NP, Crowley SD. Salt, Hypertension, and immunity. Annu Rev Physiol. 2018;80:283–307. Article CAS PubMed Google Scholar ...