Animal models form the basis of much current research to test this concept.doi:10.1016/0026-0495(95)90225-2Nicholas J. WarehamChristopher D. ByrneC.Nicholas Hales《Metabolism-clinical & Experimental》Wareham NJ, Byrne CD, Hales CN. Role of insulin and proinsulin in diabetic vascular disease. ...
Mechanistic insights into insulin resistance in the genetic era the critical role of adipose tissue in human metabolic health and the meaning and importance of 'partial' insulin resistance for major human disease.doi... VER Parker,DB Savage,S O’Rahilly,... - 《Diabetic Medicine》 被引量: 76...
4, 2005 The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Al heimer's Disease Claude Messier and Kevin Teutenberg School ofPsychology, University ofOttawa, Ottawa, Ontario, Canada K1N 6N5 ABSTRACT Most brain insulin comes from the p...
L. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat. Immunol. 6, 73–79 (2005). Article CAS PubMed Google Scholar Boismenu, R. & Havran, W. L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science...
Insulin resistance and insulin secretory dysfunction are the major metabolic defects in people with type 2 diabetes mellitus. The temporal sequence by which these abnormalities develop and their relative pathophysiologic importance at the various stages of the development of the disease continue to be the...
Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression AIM:To evaluate steatosis,insulin resistance(IR)and patatin-like phospholipase domain-containing 3(PNPLA3) and their relation to disease progression in hep... R ...
Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease Goke B and Fehmann HC. Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease. ... BGC Fehmann - 《...
Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. Consequently, zinc status is a critical factor that can influence ...
There have been in excess of 1000 publications in the field of the developmental origins of adult disease and an incorporated international society was established that exclu- sively focuses on this field of research—the Society for the Developmental Origins of Health and Disease. However, the ...
et al. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc. Natl Acad. Sci. USA 108, 18696–18701 (2011). CAS PubMed PubMed Central Google Scholar Kamili, N. A. et al. Key regulators of ...