Gut-microbiota can metabolize various quaternary amines, such as phosphatidylcholine, choline, and L-carnitine to trimethylamine (TMA). TMA is then hepatically oxidized to trimethylamine-N-oxide (TMAO). TMAO is known to promote atherosclerosis by the up-regulation of macrophage scavenger receptors and...
The Role of Gut Microbiota in Atherosclerosis and Hypertension. In recent years, accumulating evidence has indicated the importance of gut microbiota in maintaining human health. Gut dysbiosis is associated with the pat... Junli,Houkai - 《Frontiers in Pharmacology》 被引量: 2发表: 2018年 The ...
The pathogenesis of autoimmune diseases (AIDs) is not only attributed to genetic susceptibilities but also environmental factors, among which, a disturbed gut microbiota has attracted increasing attention. Compositional and functional changes of gut microbiota have been reported in various autoimmune diseases...
The essential properties of the gut microbiota, such as its stability, resilience, and diversity, need to be discussed, given its importance in human health [8]. The gut microbial community can be stable for years in healthy adults; thus, the microbiota has high stability. Homeostasis of the ...
age-related changes in vascular compliance and arterial stiffness contribute to the progression of the disease, promoting vascular remodeling and fibrosis. These changes precede hypertension and accelerate other vascular diseases, such as atherosclerosis, thereby increasing the risk of stroke and myocardial ...
Atherosclerosis 124:1-8.Beisiegel U. New aspects on the ... U Beisiegel - 《Atherosclerosis》 被引量: 125发表: 1996年 The role of ENaC in vascular endothelium Once upon a time, the expression of the epithelial sodium channel (ENaC) was mainly assigned to the kidneys, colon and sweat ...
presence of excess nutrients, a pathological transition of the gut microbial community may occur, causing leakage of bacterial products into the intestinal lymphatics and portal circulation, thereby inducing an inflammatory state, further aggravating metabolic syndrome traits and accelerating atherosclerosis. ...
In contrast, a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic (NOD) mice. Interestingly, the development of atherosclerosis in germ-free apolipoprotein E (ApoE)-deficient mice fed by a standard low-cholesterol diet is ...
The worldwide prevalence of metabolic diseases, including obesity, nonalcoholic fatty liver disease (NAFLD), insulin resistance, type 2 diabetes mellitus (T2DM), atherosclerosis (AS) and polycystic ovary syndrome (PCOS), has grown dramatically (Norman et al., 2007; Popkin et al., 2012; Younossi...
1. The human gut microbiome interaction with the immune system in age and disease 2. The gut microbiome and age-related macular degeneration 3. The gut microbiome and retinal artery occlusion 4. The gut microbiome and central serous chorioretinopathy 5. The gut microbiome and inflammatory eye ...