Role of BRCA1 mutation screen- ing in the management of familial ovarian cancer. Am J Obstet Gynecol 1996;175:738-46.Berchuck A, Cirisano F, Lancaster JM, Scholdkraut JM, Wiseman RW, Futreal A, Marks JR. Role of BRCA1 mutation screening in the management of familial ovarian cancer. ...
Furthermore, PSMD14 suppresses K63-linked ubiquitination of PKM2 and pyruvate kinase activity, which promotes its nuclear translocation and leads to aerobic glycolysis and progression of ovarian cancer [89]. Others Some other regulation of K63-linked ubiquitination also participates in the growth of ...
摘要: BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes ar关键词: central China secondary vocational education development bottleneck solutions ...
Expression of CDK1 has also been found to be increased in bladder cancer cells, parallel with over-expression of the long non-coding RNA (lncRNA) PVT1. Notably, suppression of PVT1 has decreased activity, proliferative potential, colony formation, migratory capacity, and invasiveness of bladder ...
common genetic culprits of ovarian cancer aremutationson BRCA1 and BRCA2, two genes also known to increase the risk for breast, prostate and other kinds of cancer. A patient with a mutation on their BRCA1 gene has a 40% likelihood of developing ovarian cancer, Bruce said, and BRCA2, 20...
In-person and virtual events just for HCPs CME Opportunities Choose Specialty Building the Community Oncology Practice of the Future Demands a Comprehensive Approach Microbiota Modulation Offers Hope of Expanding the Benefits of Immunotherapy Beyond the Clinic: Leveraging Research to Tackle Lung Cancer Disp...
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer m
Other common types of RCC include papillary RCC (pRCC) and chromophobe RCC (chRCC) [3]. The most commonly mutated genes in ccRCC include the von Hippel–Lindau (VHL) gene and chromatin-remodeling genes such as breast cancer 1 (BRCA1) associated-protein 1 (BAP1), SET domain-containing 2...
CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression datasets. The relationship between CD68 expressi...
Mutations in the BRCA1 gene cause strongly elevated risks of breast and ovarian cancers but may also confer a 3-fold increased risk for colorectal cancer. To address the relationship between BRCA1 carriership and colorectal tumorigenesis, we studied the genetics of a breast–ovarian cancer family ...