乳腺癌易感基因(breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。BRCA基因的两个成员,即BRCA1和2,分别是在1990年和1994年被分离。 乳腺癌可以分为遗传性乳腺癌和散发性乳腺癌(sporadic breast cancer),散发性乳腺癌指的是没有发现明确的遗传基因改变(完整的癌变点)与乳腺癌家族史的乳腺癌...
参考文献: [1]P. Torres-Mozas, F. Galvez Montosa, N. Luque Caro, et al. Descriptive analysis of the location of point mutations in BRCA and the risk of breast or ovarian cancer diagnosis. 2023 ESMO abstracts. 153P [2]D. Netto, X. Wang, B. Barnes, et al. Correlation between chemoth...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-967. doi:10.1093/carcin/bgq069 [7] Grinda T, Delaloge S. BRCA2: a 25-year journey from gene identification to targeted cancer treatment. ...
[6] O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-967. doi:10.1093/carcin/bgq069 [7] Grinda T, Delaloge S. BRCA2: a 25-year journey from gene...
[3]S. Howlett, A.M. Berner, K. Connolly, et al.Response to chemotherapy following PARP inhibition in UK ovarian cancer (OC) patients. 2023 ESMO abstracts. 800P 审批编号 CN-124731 过期日期 2024-11-15 *本材料由阿斯利康提供,...
[6] O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-967. doi:10.1093/carcin/bgq069 [7] Grinda T, Delaloge S. BRCA2: a 25-year journey from gene identific...
(including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing mortality and societal impact of these ...
An American geographer specializing in population change and urbanization in the countries of the former USSR examines nationwide and regional total, urban, and rural population change in Kazakhstan for 1989-1999, using data from the recently released 1999 Census of Kazakhstan. Of particular...