Signal Transducers and Activators of Transcription (STATs) comprise a family of transcription factors that mediate a wide variety of biological functions in the central and peripheral nervous systems. Injury to neural tissue induces STAT activation, and STATs are increasingly recognized for...
Activators often lose activity as their distance from the initiation site is increased. We show that this impaired transcriptional activity correlates with a decrease in TFIIB recruitment. Finally, we find that following the initiation of transcription, TFIIB dissociates from the promoter, requiring the...
Signal transducers and activators of transcriptionLeptin mainly acts on the hypothalamus in the brain, in which it regulates food intake and energy ... DR Sang,YY Sung,WH Jung,... - 《Molecular & Cellular Endocrinology》 被引量: 70发表: 2008年 Effect of suppressor of cytokine signaling 2 (...
Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant response element- (ARE-) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress...
et al. T cell–mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med. 187, 1225–1234 (1998). Article ...
Mediator complex has been extensively shown to regulate the levels of several protein-coding genes; however, its role in the regulation of miRNAs in humans remains unstudied so far. Here we show that MED1, a Mediator subunit in the Middle module of Media
A Role for the Conserved GAFTGA Motif of AAA+ Transcription Activators in Sensing Promoter DNA Conformation. aj SR , Buck M & Morett E ( 2007 ) A role for the conserved GAFTGA motif of AAA+ transcription activators in sensing promoter DNA conformation . ... Dago,A Ernesto,Wigneshweraraj...
Transcription factors used for inducing direct cellular reprogramming act as suppressors and activators in expressing original and induced cell-specific genes, respectively. In our previous study, Foxa1/Foxa2 and Foxa3 exhibited diverse molecular dynamics and unforeseen behaviors (Fig. 4) [22]. Only ...
Receptor tyrosine kinases are upstream activators of these signaling pathways [15–17]. Among these, fibroblast growth factor 2 (FGF2) and its receptor (FGFR) increase in reactive astrocytes, promote GFAP expression in cultured astrocytes, and are thus thought to mediate astrocytes’ reactive ...
Studying nucleosome dynamics in promoter regions is crucial for understanding gene regulation. Nucleosomes regulate gene expression by sterically occluding transcription factors (TFs) and other non–histone proteins accessing genomic DNA. How the binding