SP1 is a ubiquitous transcription factor which contains thre___motifs and two___transactivation domains. 简答题: 简述类固醇激素受体有哪些结构域?简述其调控基因转录的方式。 结构域:DNA结合结构域;转录激活结构域;二聚化结构域;配基结合结构域。 类固醇激素是脂溶性的,可以穿过细胞膜与被称作类固醇激素受体的...
Supplementary Figure 6 c-Maf is an activator of type 17 programming in γδ T cells. (a) Tγδ17-enriched CD25-CD27-γδ thymocytes populations sort purified from E17-18 Maf +/+Il7rCre (WT) and Maffl/flIl7rCre (KO) FT for RNA-seq. Plots are gated CD3ε+γδTCR+. (b) RNA ...
Signal transducer and activator of transcription-3 (STAT-3) is one of six members of a family of transcription factors. It was discovered almost 15 years ago as an acute-phase response factor. This factor has now been associated with inflammation, cellular transformation, survival, proliferation,...
a他在竞选中以28比15票胜出 正在翻译,请等待...[translate] aAn example of a eukaryotic transcription factor that works as an activator in some cell types is AP-1(activator protein-1). 运作一个eukaryotic副本因素的例子,因为一个活化计在一些细胞类型是AP-1 (活化计蛋白质1)。[translate]...
et al. Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins. J. Virol. 89, 3819–3832 (2015). Article CAS PubMed PubMed Central Google Scholar Roth,...
ABSCISIC ACID-RESPONSIVE ELEMENT BINDING PROTEIN1 (AREB1) (i.e., ABF2) is a basic domain/leucine zipper transcription factor that binds to the abscisic acid (ABA)-responsive element (ABRE) motif in the promoter region of ABA-inducible genes. Here, we show that expression of the intact ARE...
Remarkably, the transcriptional activator Met4 functions as a substrate-specificity factor in the context of SCFMet30/Met4 to coordinate cofactor degradation with its own activity status. Our results establish an additional layer for substrate recruitment by SCF ubiquitin ligases and provide conceptual ...
Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1doi:10.1016/j.ajpath.2016.10.012Mucus hypersecretion is an important pathologic feature of chronic obstructive pulmonary disease. Activating transcription factor 3 (ATF3) is ...
(Fig.1a). This provides an opportunity to test whether this transcriptional activator ofAP1can also associate with nucleosomes in vitro. After purifying recombinant LMI2 protein, we first probed LMI2 association with its binding site in the 160 bp nakedAP1regulatory DNA in vitro (Supplementary ...
Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from signifi