Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration-resistant prostate cancer, is key for its activity as transcription factor, allowing it to translocate to the nucleus and partition into transcriptional condensates upon ...
Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum Article Open access 17 March 2020 DSF inactivator RpfB homologous FadD upregulated in Bradyrhizobium japonicum under iron limiting conditions Article Open access 29 May 2023 Introduction...
Here, we studied the role of transcription factor Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) in the control of NSPCs destinies in the SGZ. We first describe that NRF2-knockout (Nrf2-/-) mice exhibit impaired long term potentiation, a function that requires integrity of the SGZ, ...
(RT-PCR) and Western blot techniques were used to observe the effects of LDP treatment on the cardiotrophin-like cytokine factor 1(CLCF1), ankyrin repeat and SOCS box containing 1(ASB1), and prokineticin 2(PROK2) genes and the Janus kinase/signal transducer and activator of transcription(JAK...
(Fig.2e); 3) up-regulation of the factor during cell transformation; 4) higher relative expression level of an individual factor of a given transcription factor family that recognize a common sequence motif. The latter two criteria were used to distinguish the contributions of the various factors...
Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters Dear Editor, Eukaryotic gene transcription is controlled by a large cohort of chromatin-associated proteins including ...
Transcription factors (TFs) such as ethylene-responsive factors (ERFs) are important for regulating plant growth, development, and responses to abiotic stress. Notably, more than half of the rice ERF-X group members, including ethylene-responsive factor
binding to short dna motifs, called transcription factor binding sites (tfbs). each tf can be connected to a set of its target genes - genes on whose promoters the tf binds in order to activate or repress them [ 2 ]. in mammalian tissues, tfs do not usually act alone but form ...
In the long-term exposure experiment, the loss of co-expression affected more genes from the modules in the GFD situation than those originating from active disease co-expression modules (14.68% vs. 12.60%, respectively). 3.2. Transcription Factor Binding Site and Gene Ontology Enrichment Analyses...
Low temperature can affect pigment accumulation by activating the MYB transcription factor [42], which is an important condition for promoting anthocyanin synthesis [10]. The R2R3-MYB transcription factor is the main MYB transcription activator in the MBW (MYB-bHLH-WD40) protein complex responsible...