RNase MRP是存在于所有真核生物中一类保守的由一条非编码RNA催化亚基和近十个蛋白质组成的核糖核酸复合物。它在核糖体rRNA前体成熟过程和细胞周期调控中都扮演着重要的角色。人源RNase MRP RNA组分的突变导致以侏儒、软骨及毛发发育不良等为显著特征的严重发育缺陷型疾病。在组成成分和进化上，RNase MRP都与体内另一类...
RNase MRP是存在于所有真核生物中一类保守的由一条非编码RNA催化亚基和近十个蛋白质组成的核糖核酸复合物。它在核糖体rRNA前体成熟过程和细胞周期调控中都扮演着重要的角色。人源RNase MRP RNA组分的突变导致以侏儒、软骨及毛发发育不良等为显著特征的严...
此次蛋白结构解析沙龙第二期中,来自上海交通大学附属第九人民医院精准医学研究院的周斌博士将为大家分享核糖核酸酶MRP蛋白质结构研究方法与进展;来自德国IBA Lifesciences的研发总监Dennis Karthaus博士将为大家分享基于Strep-tag®技术平台开发单域抗体的流程。讲座期间,达科为公司也准备了精美的礼品、试用福利、蛋白质研究...
Martin AN, Li Y (2007) RNase MRP RNA and human genetic diseases. Cell Res 17:219–226Martin AN, Li Y (2007) RNase MRP RNA and human genetic diseases. Cell Res 17:219-226Martin, A.N., and Li, Y. (2007). RNase MRP RNA and human genetic diseases. ...
Recently, it has been shown to have another substrate in the nucleus, such as pre‐5.8S ribosomal RNA in nucleolus. The gene for the RNA component of RNase MRP (MRP RNA) was found to be encoded by the nucleus genome, suggesting an interesting intracellular trafficking of MRP RNA to both ...
Furthermore, in the eukaryote RNase P has evolved into a distinct but closely related enzyme, RNase MRP. This paralogous enzyme has a structurally related RNA subunit and ten protein subunits in yeast, eight of which are also found in the RNase P enzyme. RNase MRP has distinct substrate ...
【Science | 雷鸣团队首次阐释核酶RNase MRP的催化机理】RNase MRP是存在于所有真核生物中一类保守的由一条非编码RNA催化亚基和近十个蛋白质组成的核糖核酸复合物。在组成成分和进化上,RNase MRP都与体内另一类保守且必需的核酶RNase P密切相关。但是二者具有完全不同的底物特异性和底物识别机制,功能上也不具有冗余性...
(Fig.5b) is evolutionarily conserved in terms of both the primary sequence and known structures across all kingdoms of life (Extended Data Fig.10), and is therefore of functional importance. Mutations in the pseudoknot core of human mitochondrial RNA processing RNase (RNase MRP) are linked to ...
(Fig.5b) is evolutionarily conserved in terms of both the primary sequence and known structures across all kingdoms of life (Extended Data Fig.10), and is therefore of functional importance. Mutations in the pseudoknot core of human mitochondrial RNA processing RNase (RNase MRP) are linked to ...
RNase MRP arose in an early eukaryote as a specialized form of RNase P, with a specific function in pre-rRNA processing. By analogy to RNase P, cleavage by RNase MRP is predicted to be RNA catalyzed. RNase MRP also functions in mRNA turnover, at least in yeast, initiating the cell-...