【答案】：首先在植物中发现的一种RNA指导的沉默机制。类似于：RNA干扰(RNAi)，RdI)M也需要21～26nt的双链RNA片段。与短双链RNA同源的DNA序列被甲基化，从而使基因沉默。
DNAmethylationdemethylationRdDMRNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2...
RdDM might also affect germ cell specification and parent-specific gene expression. There is increasing evidence that siRNAs are used to communicate epigenetic states between homologous sequences within a nucleus or indeed between nuclei. Abstract RNA-directed DNA methylation (RdDM) is the major small...
► De novo DNA methylation in plants can be established by the RNA-directed DNA methylation (RdDM) pathway. ► RdDM involves biogenesis of siRNAs and scaffold RNAs, and the recruitment of DNA methyltransferase. ► RdDM process appears to be spatially and temporally segregated....
RNA-directed DNA methylationseed developmentsiRNASmall RNAs trigger repressive DNA methylation at thousands of transposable elements in a process called RNA-directed DNA methylation (RdDM). The molecular mechanism of RdDM is well characterized in Arabidopsis, yet the biological function remains unclear, ...
DNA methylation typically occurs by RNA-directed DNA methylation (RdDM), which directs transcriptional gene silencing of transposons and endogenous transgenes. RdDM is driven by non-coding RNAs (ncRNAs) produced by DNA-dependent RNA polymerases IV and V (PolIV and PolV). The production of ...
RNA-directed DNA methylation (RdDM) is an epigenetic process in plants that involves both short and long noncoding RNAs. The generation of these RNAs and the induction of RdDM rely on complex transcriptional machineries comprising two plant-specific, RNA polymerase II (Pol II)-related RNA polymera...
RDDM RNA-Directed DNA Methylation RDDM Revue Des Deux Mondes (French: Review of Both Worlds; poetry) RDDM Regional Due Diligence Management RDDM Rotary Direct Drive Motors RDDM Reactor Deck Development Mockup Copyright 1988-2018 AcronymFinder.com, All rights reserved. Suggest new definitionWant...
Our results suggest that RdDM in plants is largely guided by a previously unappreciated class of Dicer-independent non-coding RNAs, and that siRNAs are required to maintain DNA methylation at only a subset of loci. Keywords: siRNA; non-coding RNA; Pol IV; Dicer-like; RdDM; DNA methylation ...
dna甲基化(dna methylation) 在甲基转移酶的催化下,dna的cg两个核苷酸的胞嘧啶被选择性地添加甲基,形成5甲基胞嘧啶,这常见于基因的5'-cg-3'序列。大多数脊椎动物基因组dna都有少量的甲基化胞嘧啶,主要集中在基因5'端的非编码区,并成簇存在。甲基化位点可随dna的复制而遗传,因为dna复制后,甲基化酶可将新合成的...