它一方面通过自身富含 精氨酸的 RNA 结合域(RNA binding domain)结合 这些病毒 mRNA,另一方面由自身单体多聚化形成 收稿 …wenku.baidu.com|基于2个网页 2. 结合区域 ... 端 (胺基酸 45~181) 具有一个 RNA 结合区域 (RNA binding domain),此种结合可以帮助病毒基因免於遭受宿主细胞的酵素 7 所破 …www....
Nucleolin is an abundant nucleolar RNA-binding protein that seems to be involved in many aspects of ribosome biogenesis. Nucleolin contains four copies of a consensus RNA-binding domain (CS-RBD) found in several other proteins. In vitro RNA-binding studies previously determined that nucleolin ...
Fig. 5: Ex vivo eRIC uncovers many novel RBPs. aFor each organ, the number of eRIC hits that are annotated RBPs, that bear a known RNA-binding domain (RBD), and that are novel RBPs (i.e., not previously reported as RBP or as bearing an RBD, and not identified in any published...
HEN1 has two domains: the N-terminal domain which binds adsRNAand the C-terminalmethyl transferasedomain. Double stranded RNA-binding motif recognizes the duplex structure produced after processing of pre-miRNA byDicer. The methyl transferase domain then inserts a 2-O-methyl group to t...
RBPs are a group of functional proteins with an RNA-binding domain (RBD) through which they can recognize particular sequences on and bind to specific target RNAs, eventually affecting RNA stability and consequent function9. Although many studies have focused on the regulation of RBP expression by...
Human Nxf1 (hereafter referred to as Nxf1) binds RNA through an N-terminal arginine-rich RNA-binding domain (RBD) and this activity is essential for mRNA export5,6. Multiple arginines wapsenliaqtdthufiowennrimtcthheefspopNorelxRycfi(N1fAiAcR)i tB+iyn DRtaenNarrdaAecbtriiiennoqnduvss...
Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor. 展开 关键词: NMR spectroscopy protein–RNA interactions RNA-binding domain tRNA synthetase ...
The conserved RNA-binding domain of Pumilio was thought to be sufficient for its function. Instead, we demonstrate that three unique domains in the N ... CA Weidmann,AC Goldstrohm - 《Molecular & Cellular Biology》 被引量: 68发表: 2011年 Circadian regulation of olfaction and an evolutionarily...
Historically, this difference was attributed to the U2AF65 arginine–serine rich domain, which contacts pre- mRNA–U2 snRNA duplexes outside of the Py tract17–19. We noticed that the RNA-binding affinity of the U2AF651,2 domain was greatly enhanced by the addition of seven and six ...
(release May 2017). Metabolic enzymes were defined as those enzymes that map to Metabolism in Reactome, plus the subunits of the ATP synthase and the respiratory chain complexes. enigmRBPs are defined as those eRIC/RIC hits that do not have a known RNA-binding domain (based on Hentze et ...