It comprises three K-homology (KH) RNA binding domains with a clear preference for C-rich sequences [3], in addition to a less characterized K interactive region (KI) that is thought to allow interaction with multiple other proteins [1]. HNRNPK plays crucial roles in several biological ...
The most widely spread motifs are the RNA recognition motif (RRM) and the K homology (KH) domain. In this article, we survey the complete Arabidopsis thaliana genome for proteins containing RRM and KH RNA-binding domains. The Arabidopsis genome encodes 196 RRM-containing proteins, a more ...
Official Full NameKH RNA binding domain containing, signal transduction associated 1 SynonymsSam68; p62; FLJ34027 Location1p35.2 Gene Typeprotein_coding Uniprot IDQ07666 Pathway/Libraryothers Gene SummaryThis gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-...
Official Full NameKH RNA binding domain containing, signal transduction associated 1 SynonymsSam68; p62; FLJ34027 Location1p35.2 Gene Typeprotein_coding Uniprot IDQ07666 Pathway/Libraryothers Gene SummaryThis gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-...
RNA, ViralRNA-Binding ProteinsHeterogeneous-Nuclear RibonucleoproteinsThe poly(rC)-binding proteins (PCBP1 and PCBP2) are RNA-binding proteins whose RNA recognition motifs are composed of three K homology (KH) domains. These proteins are involved in both the stabilization and translational regulation ...
该KHDRBS1 Polyclonal Antibody. This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell ...
There are only a few well described RNA-binding motifs, including the ribonucleoprotein (RNP) domain, arginine-glycine-glycine (RGG) boxes, zinc fingers and the heterogeneous nuclear ribonucleoprotein (hnRNP) K homology (KH) domain. Yet, the RNA repertoire is vast [3]. The KH domains are ...
We have determined the solution structure of the Gly26-->Arg mutant of the C-terminal K-homology (KH) domain of hnRNP K by NMR spectroscopy. This is the first structure investigation of hnRNP K. Backbone residual dipolar couplings, which provide information that is fundamentally different from ...
In this report, we describe a study of the flowering-time gene, FLK [flowering locus K homology (KH) domain] that encodes a putative RNA-binding protein with three KH domains. The flk mutations cause delayed flowering without a significant effect on the photoperiodic or vernalization responses....
目前主要有三个问题未得到解释:(1)Py25中包含五个胞嘧啶重复区即1,2,3,4,5,然而其主要折叠结构是1234型还是1245型仍有争议;(2)由于技术手段的限制,hnRNP K解叠c-MYC i-motif结构的微观分子动力学机理尚不清楚;(3)已有报道KH(hnRNP K-homology)结构域可以直接结合单链TCCC或CCCC序列以解开i-motif结构....