K homology domains of the mouse polycystic kidney disease-related protein, Bicaudal-C (Bicc1), mediate RNA binding in vitro. Nephron Experimental nephrology 108(1): e27-34.Bouvrette DJ,Price SJ,Bryda EC.K Homology domains of the mouse polycystic kidney disease-related protein,Bicaudal-C(Biccl...
It comprises three K-homology (KH) RNA binding domains with a clear preference for C-rich sequences [3], in addition to a less characterized K interactive region (KI) that is thought to allow interaction with multiple other proteins [1]. HNRNPK plays crucial roles in several biological ...
The most widely spread motifs are the RNA recognition motif (RRM) and the K homology (KH) domain. In this article, we survey the complete Arabidopsis thaliana genome for proteins containing RRM and KH RNA-binding domains. The Arabidopsis genome encodes 196 RRM-containing proteins, a more ...
Gene SummaryThis gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA...
PSI contains four amino-terminal hnRNP K homology (KH) RNA binding domains. Its carboxy terminus is rich in the amino acids glycine, glutamine, and alanine and contains two tandem repeats of a 70 amino acid motif of previously unknown function, the so-called AB motif (Siebel et al., 1995...
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end ...
The K-homology (KH) domain is a nucleic acid-binding domain present in many proteins but has not been reported in helicases. DDX43, also known as HAGE (helicase antigen gene), is a member of the DEAD-box protein family. It contains a helicase core domain in its C terminus and a ...
Eukaryotic cells can expand their coding ability by using their splicing machinery, spliceosome, to process precursor mRNA (pre-mRNA) into mature messenger RNA. The mega-macromolecular spliceosome contains multiple subcomplexes, referred to as small nucl
加工过程中被发现,属于hnRNP家族的一员。研究表明hnRNPK的主要功能结构为3个引导DNA—RNA连 接的KH域和一个独特的KI域。hnRNPK不仅能够通过依赖CT元件的途径或不依赖CT元件的途径在转录 水平上对基因表达进行调控,还能够通过自身的磷酸化,改变mRNA的翻译效率,以及调控基因翻译及转 ...
Like many other hnRNP proteins, hnRNP K is an RNA binding protein and gives its name to the so-called KH (K homology) domain, one of the most commonly occurring RNA binding modules, of which it has three (Siomi et al., 1993). The KH domain comprises about 70 residues with a compact...