RNA PolymeraseCellular CompartmentProduct of Transcriptionα-Amanitin Sensitivity I Nucleolus All rRNAs except 5S rRNA Insensitive II Nucleus All protein-coding nuclear pre-mRNAs Extremely sensitive III Nucleus 5S rRNA, tRNAs, and small nuclear RNAs Moderately sensitiveRNA...
RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here we report the cryo-EM structure of elongating human Pol I at 2.7 Å resolution. In the exit tunnel, we obs...
The critical events in transcription termination of RNA polymerase II (Pol II) remain not fully understood. Here, the authors find that the transcription factor Spt5 enhances the activity of RNA exonuclease Xrn2 during transcription to promote efficient termination of transcription. ...
13 Fukuda R, Iwakura Y, Ishihama A. Heterogeneity of RNA Polymerase in Escherichia coli: A New Holoenzyme Containing a New Sigma Factor. J Mol Biol. 83(3) 1974: 361–367; https://doi.org/10.1016/0022-2836(74)90284-8. ...
[1] Sousa R, Mukherjee S. T7 RNA polymerase[J]. Progress in nucleic acid research and molecular biology, 2003: 1-41. [2] Steitz T A. The structural changes of T7 RNA polymerase from tranion initiation to elongation[J]. Current opinion in structural biology, 2009, 19(6): 683-690....
[7]:《ArabidopsisRNA Polymerase IV generates 21–22 nucleotide small RNAs that can participate in RNA-directed DNA methylation and may regulate genes》(拟南芥RNA聚合酶IV产生21-22个核苷酸的小RNA,这些小RNA可以参与RNA导向的DNA甲基化,并可能调节基因)·Philosophical transactions of the Royal Society of ...
regulation of gene expression, positive regulation of GTPase activity, negative regulation of transcription, regulation of apoptotic process, viral process, lipid metabolic process, DNA-templated, cilium assembly, and regulation of transcription by RNA polymerase II were identified as the most enriched GO...
Unclassified [#IABV2_LABEL_PURPOSES#] [#IABV2_LABEL_FEATURES#] [#IABV2_LABEL_PARTNERS#] Searchfor Articles: All JournalsAcousticsActa Microbiologica Hellenica (AMH)ActuatorsAdhesivesAdministrative SciencesAdolescentsAdvances in Respiratory Medicine (ARM)AerobiologyAerospaceAgricultureAgriEngineeringAgrochemicalsAg...
In a eukaryotic context, the biogenesis of human miRNAs (hsa-miRNAs) is transcribed in the nucleus from RNA polymerase II into long primary transcripts (pri-miRNAs). The nuclear microprocessor machinery (Drosha/DGCR8) cleaves pri-miRNAs into small precursor-miRNAs (pre-miRNAs) that are then ...
dependant method, ribonucleic acid (RNA), ribonucleic acid (RNA) of especially virus, eucaryote, procaryotic living thing, and two these chains the marking and/or regards the method in order to expand and the kit in regard to, the RNA dependant RNA polymerase for biology and medicine use....