The expression of the top five highly expressed genes in each cell type; F. The barplot shows the total number of cell samples from each BC patient; G. The proportion of different cell types in each BC patient Full size image Neoadjuvant chemotherapy signature identification through integrated si...
As mentioned in the ‘Experiment design’ section, biomedical studies usually make case versus control comparisons [39]. Usually, batches of samples obtained from different medical centers or hospitals should be integrated before downstream analysis. For studies using patient-derived organoids, data inte...
Cationic/ionizable lipids can be used in the form of either liposomes or RNA/lipid complexes, such as lipoplexes and niosomes57. Fibrin gels are capable of supporting cell migration while maintaining lentivirus activity58. Fibrin-based hydrogel surface was conjugated with siRNA-loaded lipofectamine t...
Instant access to full article PDF Buy now Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support Data availability The data that support the findings in this study are available upon reasonable request from the corresponding authors. ...
Full size image VAL is important for activated AKT-induced LAD metastasis To further illustrate the functional importance of VAL in overactivated AKT-induced LAD malignancy, myr-AKT1-overexpressing A549 and HCC827 cells silenced for VAL, and the vector-control cells, were constructed and analyzed fo...
Full size image The mRNAs in this network were uploaded to DAVID to perform GO and KEGG enrichment analysis. Twenty-two enrichment terms were obtained and linked to the targeted lncRNAs and miRNAs (Fig. 5). Histone and nucleosome related biological process formed a major part of the enrichment...
Full size image The first step of data analysis is to assess and clean the raw sequencing data, which is usually provided in the form of FASTQ files [32]. Quality control visually reflects the quality of the sequencing and purposefully discards low-quality reads, eliminates poor-quality bases ...
Full size image 2. The Safety Issue 2.1 Stimulation of Innate Immune Responses In humans, survival upon infection largely depends on the ability of the immune system to detect pathogens and mount an appropriate protective immune response.[31,32] Many immune cells have the ability to sense the ...
Full size image Conservation of miRNA targets To identify miRNA target genes that may be under post-transcriptional regulation in the tammar, valid miRNA alignments not contained within a hairpin structure were surveyed. A total of 163 genes were identified using Meug_1.0 annotations as potential ta...
Show full outline Cited by (14) Figures (8) Show 2 more figures Tables (3) Table 1 Table 2 Table Extras (3) Download all Video S1. Stalk-to-stalk connection in the RNA Pol II dimer, related to Figure 3 Document S1. Figures S1–S12, Table S1, and supplemental references ...