[1]:《Plant and animal small RNA communications between cells and organisms》(植物和动物细胞中有机体之间的小RNA通讯)·Nature Reviews Molecular Cell Biology·10-2021,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208737/。 [2]:《A Neuronal piRNA Pathway Inhibits Axon Regeneration inC. elegans》(...
申涛副教授于 Taylor & Francis旗下国际期刊RNA Biology在线发表了题为The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis的综述文章,从 RNA 结合蛋白这一视角重新认识三羧酸循环酶并阐明与其结合的长非编码RNA(long non-coding RNA,lncRNA)在...
Read full chapterView PDFExplore book Viruses David P.Clark,Nanette J.Pazdernik, inMolecular Biology (Second Edition), 2013 3.2Double-Stranded RNA Viruses of Animals Double-strandedRNA virusesare relatively uncommon. Among animal viruses, the reoviruses are the best-known double-stranded RNA viruses...
12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in the coding sequence (CDS) region of an mRNA, where an I is recognized as a G or
The replication and transcription of the genome of influenza virus takes place in the nuclei of infected cells (Fig. 3).In the nucleus, the viralRNPis used astemplatefor the viralRNApolymerasecomplex (PB1, PB2, PA) to produce two different species of RNA:complementary RNA(cRNA), afull-len...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a
Transcript identification and the quantification of gene expression have been distinct core activities in molecular biology ever since the discovery of RNA’s role as the key intermediate between the genome and the proteome. The power of sequencing RNA lies in the fact that the twin aspects of dis...
Full size image Consistently, inhibitor treatments right-shifted the distribution of RNA beta coefficients (Fig.3d) and increased the averaged mRNA folding index (Fig.3e). Meanwhile, translation inhibition did not alter the folding index for long non-coding RNAs (lncRNAs) (Fig.3e), in line with...
Full size image m7G modifications in mRNA The m7G modification of eukaryotic mRNA was first discovered at its 5’ end. The RNMT/RAM methyltransferase complex uses SAM as a methyl donor to form a “cap” structure of m7G(5’)ppp(5’)X at the N7 position of guanine nucleotide [21,22,23...
Full size table As expected, when we include RIN as a covariate in the model the number of differentially expressed genes across time-points is drastically reduced (fewer than 50 genes are classified as differentially expressed between 0 hours and any other time-point; Table2). These observations...