Cryo-EM structures of full-lengthTetrahymenaribozyme at 3.1 Å resolution Cryo-electron microscopy has been used to determine the structure of theTetrahymenaribozyme (a catalytic RNA) at sufficiently high resolution to model side chains and metal ions. ...
Sign in to download full-size image Fig. 3.5.Bacterial RNA polymerase holoenzyme can recognize the core promoter. The sigma subunit of RNA polymerase allows it to bind to a specific promoter sequence (yellow) in DNA. The alpha-c-terminal domains of the enzyme can then contact the UP element...
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The replication and transcription of the genome of influenza virus takes place in the nuclei of infected cells (Fig. 3).In the nucleus, the viralRNPis used astemplatefor the viralRNApolymerasecomplex (PB1, PB2, PA) to produce two different species of RNA:complementary RNA(cRNA), afull-len...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a
[69]. APOBEC1 was first identified through the discovery of a C-to-U modification in apolipoprotein B (ApoB) mRNA, which results in the expression of two distinct forms of the protein (a truncated form and a full-length form) [71,72]. The full-length ApoB protein is responsible for ...
Full size image While the data examined here only contains a single entry for each experimental condition, RNAlysis is well suited for clustering analysis of replicate data, since it's able to cluster each batch of replicates separately and combine the results of those batches, resulting in more...
b In the hybridization stage, HCR hybridization probes anneal to the target RNA, and adjacent probes form an initiator which allows the initiation of the HCR amplification. c In the amplification stage, HCR hairpins (h1 and h2) stay self-annealing in the absence of an initiator. When an ...
Recently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME). Nevertheless, researches on the clinical significance of TIME-related lncRNAs are limited in lung adenocarcinoma (LUAD). Single-c
RNA adopts 3D structures that confer varied functional roles in human biology and dysfunction in disease. Approaches to therapeutically target RNA structures with small molecules are being actively pursued, aided by key advances in the field including the development of computational tools that predict ...