2019年5月,军事医学科学院生物医学分析中心张维娜课题组最近与美国维克森林大学Hui-Kuan Lin合作在国际顶级期刊Cell发表学术论文:Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS,发现乳酸竟然是靶向MAVS的RLR天然抑制剂,并阐明了乳酸参与RLR信号介导IFN的机理。研究...
2019年5月30日,美国Wake Forest大学林慧观教授团队(共同一作为张维娜和王桂华博士)在Cell上发表文章Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS,首次揭示了糖代谢过程中的代谢物——乳酸在先天免疫RLR信号通路中的...
报道了MAVS承载的非锚定K63泛素链激活和调控RLR抗病毒信号通路启动和转导的分子机制,并鉴定新的调控因子。 在该项研究中,研究人员首先基于体外纯化蛋白构建“RIG-I介导MAVS聚集”体外反应系统,利用该反应体系揭示MAVS上游模式识别受体RIG-I...
MAVSRLR signalingglucose metabolisminterferonlactateRLR-mediated type I IFN production plays a pivotal role in elevating host immunity for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is inactivated during RLR activation, serves as a barrier to impede type I ...
Type I IFN induction by ZIKV is almost completely abolished inMAVS-/-cells. NS4A represses RLR-, but not Toll-like receptor-mediated immune responses. NS4A specifically binds the N-terminal caspase activation and recruitment domain (CARD) of MAVS and thus blocks its accessibility by RLRs. Our...
Flavivirus TBEV prM protein inhibits RIG-I/MDA5/MAVS induced interferon production The RLRs members, such as RIG-I and MDA5, are important sensors of cytosolic viral RNA, which play a critical role in IFN-I production (Fig. 2A) [8]. We thus examined the effect of TBEV prM on RLR-med...
www.nature.com/scientificreports OPEN received: 22 April 2016 accepted: 30 August 2016 Published: 15 September 2016 Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex Zhongying Cao, Zhangchuan Xia,Yaqin Zhou, Xiaodan Yang, Hua Hao, ...
BAG6 negatively regulates theRLR signaling pathway bytargeting VISA/MAVSJing-Ping Huang, Jing Li, Yan-Ping Xiao and Liang-Guo Xu *College of Life Science, Jiangxi Normal University, Nanchang, ChinaThe virus-induced signaling adaptor protein VISA (also known as MAVS, ISP-1,Cardif) is a critica...
2019年5月,军事医学科学院生物医学分析中心张维娜课题组最近与美国维克森林大学Hui-Kuan Lin合作在国际顶级期刊Cell发表学术论文:Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS,发现乳酸竟然是靶向MAVS的RLR天然抑制剂,并阐明了乳酸参与RLR信号介导IFN的机理。
2019年5月,军事医学科学院生物医学分析中心张维娜课题组最近与美国维克森林大学Hui-Kuan Lin合作在国际顶级期刊Cell发表学术论文:Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS,发现乳酸竟然是靶向MAVS的RLR天然抑制剂,并阐明了乳酸参与RLR信号介导IFN的机理。