RLR signaling pathwayIFN responseMammalian mitochondrial antiviral signaling protein (MAVS) is an essential adapter involved in retinoic acid-inducible gene-I (RIG-I)-like receptor (RLR)-triggered interferon (IFN) antiviral immunity. Fish MAVS homologues have been identified in several fish species; ...
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex. Protein Cell. 2014;5(5):369–81. Article CAS Google Scholar Esser-Nobis K, Hatfield LD, Gale M. Jr. Spatiotemporal dynamics of innate immune signaling ...
Hepatitis A, B, and C viruses can interact with MAVS and block the intracellular signaling pathway at the level of MAVS19. An autoinhibitory mechanism that modulates MAVS activity in unstimulated cells, thus ensuring a prompt response of MAVS to virus infection, has been also reported20. Methyl...
BAG6 negatively regulates theRLR signaling pathway bytargeting VISA/MAVSJing-Ping Huang, Jing Li, Yan-Ping Xiao and Liang-Guo Xu *College of Life Science, Jiangxi Normal University, Nanchang, ChinaThe virus-induced signaling adaptor protein VISA (also known as MAVS, ISP-1,Cardif) is a critica...
RLR signalingMitochondrial antiviral signaling (MAVS) protein is a core signaling adapter in the retinoid acid–inducible gene-I–like receptor (RLR) signaling pathway that recruits downstream signaling factors, ultimately leading to the activation of type Ⅰ interferons. However, the mechanisms that ...
(A) Scheme of selected reactions in glucose metabolic pathway. (B) Analysis of HK activity in purified mitochondria isolated from HEK293 cells transfected with poly(I:C). (C) qPCR analysis of IFN-β mRNA expression in control or HK2 knockdown Hep3B cells transfected with or without poly(I:...
Molecular cloning, identification and expression analysis of MDA5/MAVS/TRAF3/TANK/TBK1, five pivotal molecules of RLR signalling pathway in turbot (Scophthalmus maximus)gene expressioninnate antiviral immunitypattern recognition receptorpoly (I:C)Scophthalmus maximus...