在Ritter反应中，以苯甲醇为例，其反应机理可以这样描述：首先，苯甲醇中的羟基发生质子化，随后，质子化的苯甲醇以水的形式脱离，留下一个带正电荷的碳原子。此时，氰乙酸甲酯中的氰基N原子会亲核进攻这个带正电荷的碳原子，生成一个腈正离子。通过共振作用，正电荷会从腈正离子中转移到电负性更小的碳原子上。最...
A solution of 1-adamantanol (0.304 g, 2 mmol)and urea (0.24 g, 4 mmol) in TFA (1.54 mL, 20 mmol) was heated at 115-120oCfor 7 hr. After the reaction was complete, the mixture was kept at r.t.overnight. Then acetone (2 mL) was added to and precipitate...
ritter reaction Ritter反应使用强质子酸、水或溶剂将腈和碳正离子前体分子转化为酰胺。首先，前体分子在强酸的作用下变成碳正离子，腈的氮原子攻击此碳正离子后形成腈鎓离子。然后，当酸的共轭碱（本例中为硫酸氢阴离子）加入到腈鎓离子中时，形成亚胺酸盐（imidate）。经过质子转移，水解产生所需的N-取代酰胺产品...
里特反应(Ritter Reaction) Ritter反应使用强质子酸、水或溶剂将腈和碳正离子前体分子转化为酰胺。首先,前体分子在强酸的作用下变成碳正离子,腈的氮原子攻击此碳正离子后形成腈鎓离子。然后,当酸的共轭碱(本例中为硫酸氢阴离子)加入到腈鎓离子中时,形成亚胺酸盐(imidate)。经过质子转移,水解产生所需的N-取代酰胺...
2. https://www.organic-chemistry.org/namedreactions/ugi-reaction.shtm 3. a) https://pubs.acs.org/ b) https://onlinelibrary.wiley.com/ c) https://www.sciencedirect.com/ d) https://www.rsc.org/ e) https://www.thieme-connect.com/ f) http://www.sciencemag.org/ ...
A solution of 1-adamantanol (0.304 g, 2 mmol)and urea (0.24 g, 4 mmol) in TFA (1.54 mL, 20 mmol) was heated at 115-120oCfor 7 hr. After the reaction was complete, the mixture was kept at r.t.overnight. Then acetone (2 mL) was added to and precipitate was formed. Thecrude...
里特反应(Ritter Reaction)是构建 C─N 键的有力合成工具。自 1948 年被发现以来,在过去的七十年间,合成化学家、药物化学家以及材料化学家对其展开了广泛研究,并取得了诸多重要成果。尽管已有不少优秀的综述和书籍记录了这些进展,但将里特反应作为天然生物碱全合成关键步骤进行全面综述的研究还未曾出现。
A solution of 1-adamantanol (0.304 g, 2 mmol)and urea (0.24 g, 4 mmol) in TFA (1.54 mL, 20 mmol) was heated at 115-120oCfor 7 hr. After the reaction was complete, the mixture was kept at r.t.overnight. Then acetone (2 mL) was added to and precipitate was formed. Thecrude...
ritter reaction 英 美 [ˈrɪtər riˈækʃn]网络 里特反应; Ritter反应
A solution of 5.3 g (0.1 mol ) of acrylonitrile, 50 ml of acetic acid and 7.4 g of t butylalcohol in an ice-bath was treated with conc. sulfuric acid (10.1 g, 0.1 mol) with stirring so as to keep the temperature below 40 ℃ during the addition and subsequent reaction (an hour),...