在Ritter反应中，以苯甲醇为例，其反应机理可以这样描述：首先，苯甲醇中的羟基发生质子化，随后，质子化的苯甲醇以水的形式脱离，留下一个带正电荷的碳原子。此时，氰乙酸甲酯中的氰基N原子会亲核进攻这个带正电荷的碳原子，生成一个腈正离子。通过共振作用，正电荷会从腈正离子中转移到电负性更小的碳原子上。最...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74...
20 mmol) was heated at 115-120oCfor 7 hr. After the reaction was complete, the mixture was kept at r.t.overnight. Then acetone (2 mL) was added to and precipitate was formed. Thecrude product was filtratrated after cooling, washed with pentane and dried togive 0.43 g ...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74,2207-2209. ...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 11. Yadav, J. S.; Reddy, Y. J.; Reddy, P. A. N.; Reddy, B. V. S. Org. Lett. 2013, 15, 546-549. ...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74,2207-2209. ...
Ritter reactionThe Ritter reaction is a method of choice for the production of amides, which are versatile intermediates in organic synthesis and compounds of interest in natural product synthesis. Recent efforts have been directed towards the development of catalytic versions for the development of ...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74,2207-2209. ...
9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review). 10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74,2207-2209. ...