and in patients with hepatic impairment due to an increase in the free fraction of the drug. Coadministration of CYP2D6 and/or CYP3A inhibitors (e.g. clozapine and fluoxetine) may interfere with the conversion of risperidone to 9-hydroxyrisperidone, whereas coadministration ...
Investigating differential drug effects on brain metabolite levels in an animal model, McLoughlin and colleagues report antipsychotic induced reductions of glutamate in the frontal cortex only with clozapine and olanzapine, but not risperidone, haloperidol, or aripiprazole47. This is further supported by ...
Moreover, differential anti-hallucinatory effectiveness was found in the primary intention-to-treat analyses among the drugs since ziprasidone and quetiapine were both superior to risperidone in reducing the hallucination score, with olanzapine in an intermediate position, when the patients were followed f...
and in patients with hepatic impairment due to an increase in the free fraction of the drug. Coadministration of CYP2D6 and/or CYP3A inhibitors (e.g. clozapine and fluoxetine) may interfere with the conversion of risperidone to 9-hydroxyrisperidone, whereas coadministration ...