(which correspond to 39, 78, 117, 156, and 234 mg of paliperidone palmitate) respectively (ie 25‐fold dose conversion factor from oral risperidone to PP1M. Conclusions This study provides clinicians with a practical guidance to establish suitable maintenance dose levels of PP1M and oral ...
Known hypersensitivity to risperidone, paliperidone, or to any excipients in risperidone (4) Warnings and Precautions • Cerebrovascular events, including stroke, in elderly patients with dementia-related psychosis: risperidone is not approved for use in patients with dementia-related psychosis. (5.2) ...
Bone length and density were decreased with a no-effect dose of 0.31 mg/kg/day; this dose produced plasma AUC of risperidone plus its active metabolite paliperidone (9-hydroxyrisperidone) that were similar to those in children and adolescents receiving the MRHD of 6 mg/day. In addition, ...
The efficacy of RISPERDAL CONSTA®in the treatment of schizophrenia has not been evaluated in controlled clinical trials for longer than 12 weeks. Although controlled studies have not been conducted to answer the question of how long patients with schizophrenia should be treated with RISPERDAL CONST...
“Antibodies to Paliperidone Haptens and Use Thereof” (U.S. Provisional Patent Application No. 61/691,634, filed Aug. 21, 2012, Attorney Docket No. CDS5126USPSP), “Antibodies to Quetiapine Haptens and Use Thereof” (U.S. Provisional Patent Application No. 61/691,598, filed Aug. 21,...
However, many of the therapeutic benefits of risperidone are due to its conversion to its active moiety 9-hydroxyrisperidone. 9-hydroxyrisperidone can be administered directly through the newer atypical antipsychotic paliperidone. Paliperidone has been shown to exhibit weak affinity for alpha-1 and ...
Bone length and density were decreased with a no-effect dose of 0.31 mg/kg/day; this dose produced plasma AUC of risperidone plus its active metabolite paliperidone (9-hydroxyrisperidone) that were similar to those in children and adolescents receiving the MRHD of 6 mg/day. In addition, ...