Due to persistent hallucinations, self-talking and persecutory delusions, risperidone was switched to extended-release paliperidone 3 mg/day [ route not stated ]; her other medications were not changed. After 2 months, she experienced involuntary, rapid, vertical, rhythmic movements of her mouth. ...
Risperidone and paliperidone have similar receptor binding profiles, although there are some differ- ences. While paliperidone antagonizes central dopamine D2 and serotonin 5-HT2A receptors as well as alpha1- and alpha 2-adrenergic receptors and H1 histaminergic receptors, the risperidone 5-HT2A/D2...
Paliperidone, a long-acting second-generation antipsychotic, has been shown to reduce acute schizophrenia symptoms and provide clinical benefits in both acute and maintenance therapy in adults [5]. Typically, paliperidone (9-OH-risperidone) is a pharmacologically active metabolite of risperidone with a...
The objective of this study was to investigate the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives (PDs) compared with paliperidone and risperidone. The i.g. LD50 and i.v. maximum tolerated doses of PD1, PD5 and PD6 were greater than those of paliperidone and ...
Adjunctive aripiprazole in the treatment of risperidone/paliperidone-induced hyperprolactinemia. Influence of catechol-O-methyltransferase and MAOA polymorphismsAim: We examined the association of COMT haplotypes and plasma metabolites of catecholamines in relation to the clinical response to antipsychotics in ...