Three of these studies also included an active control group consisting of either risperidone (one trial) or haloperidol (two trials), but they were not designed to allow for a comparison of aripiprazole and the active comparators. In the four positive trials for aripiprazole, four primary ...
For the primary endpoint (PANSS scores), aripiprazole was superior to placebo or equivalent to active comparators (risperidone, olanzapine or haloperidol). These short-term studies revealed a range of effective doses from 10mg/day to 20mg/day. Five studies, lasting between 16and 52weeks, with a...
3.6Risperidone Consta® In one studyrisperidoneConsta® doses between 25 and 75mg/2weeks were compared with a placebo (Janssen;Kane et al., 2003a). 25mg/2weeks was the minimum effective dose, leading to a 1mg olanzapine equivalent of 0.12mg. ...
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco....
Based on the assumptions above and the fact that compartmental distribution volumes are equivalent to the ratio of the AUC to infinity of the compartment to the AUC of the arterial plasma, and denoting the specifically bound compartment CS, the right-hand side of this expression simplifies to ...
The injection intervals for LAIs depend on the specific agent (e.g. every 4 weeks for aripiprazole, haloperidol, and paliperidone; every 2 weeks for risperidone, etc.) and are based on extensive pharmacokinetic studies of patients as well as computer simulations [10]. Although not extensively ...
This could possibly be due to the lower starting and subsequent dose as compared to that of the previous study. These results suggest that this study's titration strat- egy provides an appropriate treatment approach for the use of aripiprazole in this population. Aripiprazole and risperidone are ...
which was titrated to 5 mg after 2 days and to the target dose of 10 mg after 2 additional days. Subsequent dose increases should be administered in 5 mg increments. The 30 mg/day dose was not shown to be more efficacious than the 10 mg/day dose. Aripiprazole can be administered withou...
Risperidone Ritonavir Ropeginterferon Alfa-2b-njft Selpercatinib Sertindole Sertraline Sevoflurane Siponimod Sodium Oxybate Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol St John's Wort Sufentanil
dose for an orally administered aripiprazole formulation is fifteen (15) milligrams. In order to administer a drug dose equivalent to one (1) to more than eight (8) weeks of the oral dosage quantity requires the administration of a very large amount of the drug as a single dose. The ...