RING box-1p27multiple myelomadrug resistancebone marrowF-box proteinMultiple myeloma (MM) is a clonal disease of plasma cells that remains, for the most part, incurable despite the advent of several novel therapeutics. The elevated expression of p27 and its association with cell-cycle arrest is...
我们的工作确定大麦中的RING/U-box E3泛素连接酶BIR1是BLF1蛋白水平的假定调节因子。 虽然大麦中BLF1在泛素化中的直接作用需要进一步验证,但我们认为这是一种非常合理的情况,因为BIR1蛋白可以在异源系统中特异性地泛素化BLF1,并且发现大麦中的蛋白酶体降解会使BLF1-vYFP转变。如果得到证实,BIR1的这种功能将增加我...
cIAP2/BIRC3BIRC3apoptosis inhibitor 2, cIAP2, c-IAP2, hiap-1, inhibitor of apoptosis protein 1, MALT2, mammalian IAP homolog C, MIHC, RNF49, TNFR2-TRAF signaling complex protein Livin/BIRC7BIRC7KIAP, kidney inhibitor of apoptosis protein, livin, livin inhibitor-of-apoptosis, melanoma inhibi...
57,58 This CRLVif includes Elongin (ELO) B/C, Cullin (CUL) 5, RING-box protein (Rbx) 2 and the cofactors core binding factor-β as well as the Ariadne RING-in-between-RING (RBR) E3 ubiquitin protein ligase (ARIH2).59, 60, 61, 62, 63 This complex polyubiquitinates the cytoplasmic...
Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions including the neocortex and ganglionic eminence. While Bone morphogenetic protein (BMP), Wnt, and Sonic hedgehog (Shh) signaling are k
SPL1, a U-box protein with E3 Ubi ligase activity, contains both a U-box domain and an armadillo repeat domain, while XB3, an XA21-binding protein with E3 Ubi ligase activity, has an ankyrin repeat do- main in its N-terminus in addition to a RING domain at its C-terminus [30, ...
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The side chain of Y526 is found in an unusual conformation in the crystal structure (Protein Data Bank (PDB) code 2FPE (ref.31), Extended Data Table1), characterized by aχ2dihedral angle of 2° (Fig.1a). Normally, this eclipsed conformation is energetically unfavourable because of steric...
As TaHRP1 is homologous to the forkhead box protein B2 that binds to a cis-acting element27, we hypothesized that TaHRP1 acts as a transcription factor in the nucleus. To test this hypothesis, we first confirmed the predicted NLS in the C-terminal region. Upon transient expression of TaHRP1...
Instead a noncanonical PRC1 complex containing a third PCGF protein, L(3)73Ah as a RING partner is responsible for much of the H2AK118ub [11]. In mammals there are two RING homologs, RING1 and RING2 (also known as RING1A and RING1B) of which RING2 is the more abundant. Mammals...