By sequence similarity, Ro52 belongs to the RING-B-box-coiled-coil (RBCC) protein family. Disease-related antibodies bind Ro52 in a conformation-dependent way both in the coiled-coil region and in the Zn2+-binding Ring-B-box region. Primarily associated with Sjögren syndrome, Ro52 ...
D, COS and HeLa cells were transfected with pcDNA-Hls5-Myc, and 24 h later, the protein was localized by confocal microscopy using an anti-Myc antibody. DNA was identified by Hoescht staining. As Hls5 was isolated from an erythroid to myeloid lineage switch, the expression pattern of Hls5...