In the structure of the BARD1-BRCA1 heterodimer, the BRCA1 RING motif is flanked by N- and C-terminal helices that interact to form the heterodimer binding surface (27). Although the BRCA1 is not an RBCC protein, and the helical sequences flanking its RING are not conserved in Ro52, ...
D, COS and HeLa cells were transfected with pcDNA-Hls5-Myc, and 24 h later, the protein was localized by confocal microscopy using an anti-Myc antibody. DNA was identified by Hoescht staining. As Hls5 was isolated from an erythroid to myeloid lineage switch, the expression pattern of Hls5...